Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation

• Published in: The journal of clinical endocrinology and metabolism Vol. 101; no. 9; pp. 3469 - 3478
• Main Authors: Rossi, Francesca, Bellini, Giulia, Luongo, Livio, Manzo, Iolanda, Tolone, Salvatore, Tortora, Chiara, Bernardo, Maria Ester, Grandone, Anna, Conforti, Antonella, Docimo, Ludovico, Nobili, Bruno, Perrone, Laura, Locatelli, Franco, Maione, Sabatino, del Giudice, Emanuele Miraglia
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.09.2016
• Subjects: Adipocytes, Brown - immunology; Adipocytes, Brown - pathology; Adipose tissue; Adipose Tissue - immunology; Adipose Tissue - pathology; Adult; Age; Agonists; Animals; Biomarkers - analysis; Biopsy; Body fat; Body mass index; Bone surgery; Cannabinoid CB2 receptors; Case-Control Studies; Child; Children; Drug development; Female; Follow-Up Studies; Food intake; Humans; Hyperplasia; Hypertrophy; Inflammation; Inflammation - genetics; Inflammation - immunology; Inflammation - pathology; Italy; Male; Mesenchymal stem cells; Mice; Mutation - genetics; Obesity; Obesity - drug therapy; Obesity - genetics; Obesity - pathology; Prognosis; Receptor, Cannabinoid, CB2 - agonists; Receptor, Cannabinoid, CB2 - genetics; Stem cell transplantation

Context:Obesity is associated with a low-grade inflammatory state and adipocyte (ADP) hyperplasia/hypertrophy. Obesity inhibits the “browning” of white adipose tissue. Cannabinoid receptor 2 (CB2) agonists reduce food intake and induce antiobesity effect in mice. A common missense CB2 variant, Q63R,...