Investigating the neuroimmunogenic architecture of schizophrenia

• Published in: Molecular psychiatry Vol. 23; no. 5; pp. 1251 - 1260
• Main Authors: Birnbaum, R, Jaffe, A E, Chen, Q, Shin, J H, Kleinman, J E, Hyde, T M, Weinberger, D R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2018; Nature Publishing Group
• Subjects: 631/208; 631/378; 692/699/476/1799; Adult; Autopsy; Behavioral Sciences; Biological Psychology; Brain - pathology; Female; Gene expression; Gene Expression Profiling; Hippocampus; Humans; Immune response; Immune system; Male; Medicine; Medicine & Public Health; Mental disorders; Middle Aged; Neuroimmunomodulation; Neurosciences; Oligonucleotide Array Sequence Analysis; original-article; Peripheral blood; Pharmacotherapy; Prefrontal cortex; Psychiatry; Ribonucleic acid; RNA; Schizophrenia; Schizophrenia - genetics; Schizophrenia - immunology; Schizophrenia - pathology; Sequence Analysis, RNA
• ISSN: 1359-4184; 1476-5578; 1476-5578
• DOI: 10.1038/mp.2017.89

The role of the immune system in schizophrenia remains controversial despite numerous studies to date. Most studies have profiled expression of select genes or proteins in peripheral blood, but none have focused on the expression of canonical pathways that mediate overall immune response. The curren...