Investigation of the Interaction Between N-benzyl Piperidones and Bovine Serum Albumin by Spectroscopic Approaches

• Published in: Journal of solution chemistry Vol. 41; no. 10; pp. 1747 - 1758
• Main Authors: Yu, Xianyong, Yao, Qing, Li, Wei, Liao, Xuecheng, Yang, Ying, Liu, Heting, Li, Xiaofang, Yi, Pinggui
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.11.2012; Springer
• Subjects: bovine serum albumin; Chemistry; Chemistry and Materials Science; Condensed Matter Physics; energy transfer; Exact sciences and technology; fluorescence; fluorescence emission spectroscopy; General and physical chemistry; Geochemistry; hydrogen; Industrial Chemistry/Chemical Engineering; Inorganic Chemistry; Oceanography; Physical Chemistry; Solutions; thermodynamics; tryptophan; van der Waals forces; Fluorescence spectroscopy; Bovine serum albumin; benzyl piperidones; Ultraviolet spectroscopy; Bovine; Theory; N-benzyl piperidones; Fluorescence; Tryptophan; Serum albumin; Vertebrata; Mammalia; Binding capacity; Residue; Thermodynamic parameter; Van der Waals interaction; Artiodactyla; Energy transfer; Ungulata; Conformation; Hydrogen bond

Fluorescence and ultraviolet spectroscopies were applied to investigate the interaction between five N -benzyl piperidones (NBP) and bovine serum albumin (BSA) under imitated physiological conditions. The experimental results show that these NBPs have a static fluorescence quenching effect on the en...