Ajulemic acid, a synthetic cannabinoid acid, induces an antiinflammatory profile of eicosanoids in human synovial cells
To better understand mechanisms whereby Ajulemic acid (AjA), a synthetic antiinflammatory cannabinoid, promotes resolution of acute and chronic inflammation in animal models, we investigated its influence on cyclooxygenase 2 (COX2) expression and eicosanoid production in human fibroblast-like synovi...
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Published in | Life sciences (1973) Vol. 83; no. 19; pp. 666 - 670 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
07.11.2008
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Abstract | To better understand mechanisms whereby Ajulemic acid (AjA), a synthetic antiinflammatory cannabinoid, promotes resolution of acute and chronic inflammation in animal models, we investigated its influence on cyclooxygenase 2 (COX2) expression and eicosanoid production in human fibroblast-like synovial cells (FLS).
FLS isolated from tissue obtained at joint replacement surgery or cultured from synovial fluid were treated for 60 min with AjA (10–30 μM), then stimulated with tumor necrosis factor α (TNFα). COX2 mRNA was measured by hybridization/colorimetric assay of whole cell lysates collected 4 h after stimulation. To determine effects on arachidonic acid release, FLS were incubated with
14C-arachidonic acid for 20 h then treated with AjA (8–32 μM). Arachidonic acid release was measured by scintillation counting. Prostaglandins (PG) were measured by enzyme linked immunosorbent assay (ELISA) in cell supernatants collected 4 and 24 h after stimulation.
AjA increased the steady state levels of COX2 mRNA in and arachidonic acid release from FLS. Treatment of FLS with AjA increased 15-deoxy-delta
12,14-PGJ
2 (15d-PGJ
2) production in a concentration dependent manner, but did not affect PGE
2 production significantly.
The capacity of AjA to increase selectively and markedly 15d-PGJ
2, an eicosanoid which facilitates resolution of inflammation, suggests that AjA may have value as a therapeutic agent for the treatment of rheumatoid arthritis (RA) and other diseases characterized by acute and chronic inflammation. |
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AbstractList | AIMSTo better understand mechanisms whereby Ajulemic acid (AjA), a synthetic antiinflammatory cannabinoid, promotes resolution of acute and chronic inflammation in animal models, we investigated its influence on cyclooxygenase 2 (COX2) expression and eicosanoid production in human fibroblast-like synovial cells (FLS). MAIN METHODSFLS isolated from tissue obtained at joint replacement surgery or cultured from synovial fluid were treated for 60 min with AjA (10-30 microM), then stimulated with tumor necrosis factor alpha (TNFalpha). COX2 mRNA was measured by hybridization/colorimetric assay of whole cell lysates collected 4 h after stimulation. To determine effects on arachidonic acid release, FLS were incubated with (14)C-arachidonic acid for 20 h then treated with AjA (8-32 microM). Arachidonic acid release was measured by scintillation counting. Prostaglandins (PG) were measured by enzyme linked immunosorbent assay (ELISA) in cell supernatants collected 4 and 24 h after stimulation. KEY FINDINGSAjA increased the steady state levels of COX2 mRNA in and arachidonic acid release from FLS. Treatment of FLS with AjA increased 15-deoxy-delta(12,14)-PGJ(2) (15d-PGJ(2)) production in a concentration dependent manner, but did not affect PGE(2) production significantly. SIGNIFICANCEThe capacity of AjA to increase selectively and markedly 15d-PGJ(2), an eicosanoid which facilitates resolution of inflammation, suggests that AjA may have value as a therapeutic agent for the treatment of rheumatoid arthritis (RA) and other diseases characterized by acute and chronic inflammation. To better understand mechanisms whereby Ajulemic acid (AjA), a synthetic antiinflammatory cannabinoid, promotes resolution of acute and chronic inflammation in animal models, we investigated its influence on cyclooxygenase 2 (COX2) expression and eicosanoid production in human fibroblast-like synovial cells (FLS). FLS isolated from tissue obtained at joint replacement surgery or cultured from synovial fluid were treated for 60 min with AjA (10–30 μM), then stimulated with tumor necrosis factor α (TNFα). COX2 mRNA was measured by hybridization/colorimetric assay of whole cell lysates collected 4 h after stimulation. To determine effects on arachidonic acid release, FLS were incubated with 14C-arachidonic acid for 20 h then treated with AjA (8–32 μM). Arachidonic acid release was measured by scintillation counting. Prostaglandins (PG) were measured by enzyme linked immunosorbent assay (ELISA) in cell supernatants collected 4 and 24 h after stimulation. AjA increased the steady state levels of COX2 mRNA in and arachidonic acid release from FLS. Treatment of FLS with AjA increased 15-deoxy-delta 12,14-PGJ 2 (15d-PGJ 2) production in a concentration dependent manner, but did not affect PGE 2 production significantly. The capacity of AjA to increase selectively and markedly 15d-PGJ 2, an eicosanoid which facilitates resolution of inflammation, suggests that AjA may have value as a therapeutic agent for the treatment of rheumatoid arthritis (RA) and other diseases characterized by acute and chronic inflammation. To better understand mechanisms whereby Ajulemic acid (AjA), a synthetic antiinflammatory cannabinoid, promotes resolution of acute and chronic inflammation in animal models, we investigated its influence on cyclooxygenase 2 (COX2) expression and eicosanoid production in human fibroblast-like synovial cells (FLS). FLS isolated from tissue obtained at joint replacement surgery or cultured from synovial fluid were treated for 60 min with AjA (10-30 microM), then stimulated with tumor necrosis factor alpha (TNFalpha). COX2 mRNA was measured by hybridization/colorimetric assay of whole cell lysates collected 4 h after stimulation. To determine effects on arachidonic acid release, FLS were incubated with (14)C-arachidonic acid for 20 h then treated with AjA (8-32 microM). Arachidonic acid release was measured by scintillation counting. Prostaglandins (PG) were measured by enzyme linked immunosorbent assay (ELISA) in cell supernatants collected 4 and 24 h after stimulation. AjA increased the steady state levels of COX2 mRNA in and arachidonic acid release from FLS. Treatment of FLS with AjA increased 15-deoxy-delta(12,14)-PGJ(2) (15d-PGJ(2)) production in a concentration dependent manner, but did not affect PGE(2) production significantly. The capacity of AjA to increase selectively and markedly 15d-PGJ(2), an eicosanoid which facilitates resolution of inflammation, suggests that AjA may have value as a therapeutic agent for the treatment of rheumatoid arthritis (RA) and other diseases characterized by acute and chronic inflammation. |
Author | Johnson, David R. Zurier, Robert B. Stebulis, Judith A. Burstein, Sumner H. Rossetti, Ronald G. |
Author_xml | – sequence: 1 givenname: Judith A. surname: Stebulis fullname: Stebulis, Judith A. email: judith.stebulis@umassmed.edu organization: UMass Memorial Medical Center, Rheumatology Division, 119 Belmont Street, Worcester, MA 01605, USA – sequence: 2 givenname: David R. surname: Johnson fullname: Johnson, David R. organization: Environmental Laboratory, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Rd., Vicksburg, MS 39180, USA – sequence: 3 givenname: Ronald G. surname: Rossetti fullname: Rossetti, Ronald G. organization: University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA – sequence: 4 givenname: Sumner H. surname: Burstein fullname: Burstein, Sumner H. organization: University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA – sequence: 5 givenname: Robert B. surname: Zurier fullname: Zurier, Robert B. organization: University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA |
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Cites_doi | 10.1002/art.1780280511 10.1038/9550 10.1006/bbrc.2001.4847 10.1074/jbc.274.12.8328 10.1006/jaut.2000.0435 10.1074/jbc.M001387200 10.2337/diabetes.49.3.346 10.1038/34178 10.1073/pnas.96.8.4668 10.1001/jama.290.13.1757 10.1021/jm00095a007 10.4049/jimmunol.168.12.6232 10.1161/01.ATV.19.9.2094 10.1002/jcb.21046 10.1073/pnas.97.9.4844 10.1073/pnas.95.24.14540 10.1096/fj.02-0485fje 10.1146/annurev.biochem.69.1.145 10.1074/jbc.M309409200 10.1038/83336 10.1038/34184 10.1002/art.10055 10.4049/jimmunol.171.10.5148 10.1053/joca.2002.0835 10.1126/science.176.4033.422 10.1161/01.CIR.101.3.235 10.1124/mol.61.5.997 10.1074/jbc.M402828200 10.1002/1529-0131(199801)41:1<163::AID-ART20>3.0.CO;2-9 10.1002/art.20050 10.1016/S1521-6616(03)00064-0 10.1074/jbc.M007688200 10.1007/BF00290266 10.1172/JCI9652 10.1084/jem.163.6.1509 10.1016/S0006-2952(02)01604-0 10.4049/jimmunol.167.1.469 10.1002/art.1780380922 10.1016/0092-8674(95)90193-0 10.1096/fj.02-1162fje 10.1124/jpet.106.111625 10.1186/ar1830 10.1016/j.pain.2005.03.037 10.1124/mol.63.5.983 10.4049/jimmunol.166.12.7104 10.1074/jbc.M104036200 10.4049/jimmunol.171.2.979 |
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References | Müller-Ladner, Kriegsmann, Gay, Koopman, Gay, Chatham (bib29) 1995; 38 Abramson, Weissmann (bib1) 1989; 7 Müller-Ladner, Kreigsmann, Franklin, Matsumoto, Geiler, Gay (bib30) 1996; 149 Straus, Pascual, Li, Welch, Ricote, Hsiang (bib43) 2000; 97 Bianchi, Moulin, Sebillaud, Koufany, Galteau, Netter (bib2) 2005; 7 Vann, Cook, Martin, Wiley (bib47) 2007; 320 Kawahito, Kondo, Tsubouchi, Hashiramoto, Bishop-Bailey, Inoue (bib24) 2000; 106 Petrova, Akama, Van Eldik (bib36) 1999; 96 Faour, He, He, de Ladurantaye, Quintero, Mancini (bib13) 2001; 276 O'Sullivan, Fassbender, Gay, Koopman (bib32) 1985; 28 Robinson, Skoskiewicz, Bloch, Castorena, Hayes, Lowenstein (bib39) 1986; 163 Bingham (bib4) 2002; 65 Kalajdzic, Faour, He, Fahmi, Martel-Pelletier, Pelletier (bib22) 2002; 46 Liu, Li, Burstein, Zurier, Chen (bib26) 2003; 63 Dyson, Peacock, Chen, Courade, Yaqoob, Groarke (bib11) 2005; 116 Inoue, Tanabe, Umesono (bib18) 2000; 275 Zurier, Rossetti, Burstein, Bidinger (bib52) 2003; 65 Chawla, Barak, Nagy, Liao, Tontonoz, Evans (bib7) 2001; 7 Smith, DeWitt, Garavito (bib40) 2000; 69 Forman, Tontonoz, Chen, Brun, Spiegelman, Evans (bib14) 1995; 83 Fahmi, Pelletier, Mineau, Martel-Pelletier (bib12) 2002; 10 Ricote, Li, Wilson, Kelly, Glass (bib38) 1998; 391 Tanaka, O'Sullivan, Koopman, Gay (bib45) 1988; 15 Johnson, Stebulis, Rosssetti, Burstein, Zurier (bib21) 2007; 100 Maggi, Sadeghi, Weigand, Scarim, Heitmeier, Corbett (bib27) 2000; 49 Jackson, Parhami, Xi, Berliner, Hsueh, Law (bib19) 1999; 19 Sumariwalla, Gallily, Tchilibon, Fride, Mechoulam, Feldmann (bib44) 2004; 50 Perez-Sala, Cernuda-Morollon, Canada (bib35) 2003; 278 Cheng, Afif, Martel-Pelletier, Pelletier, Li, Farrajota (bib9) 2004; 279 Gilroy, Colville-Nash, McMaster, Sawatzky, Willoughby, Lawrence (bib17) 2003; 17 Stichtenoth, Thorén, Bian, Peters-Golden, Jakobsson, Crofford (bib42) 2001; 167 Burstein, Audette, Breuer, Devane, Colodner, Doyle (bib6) 1992; 35 Pasceri, Wu, Willerson, Yeh (bib34) 2000; 101 Zurier, Rossetti, Lane, Goldberg, Hunter, Burstein (bib51) 1998; 41 Zernecke, Erl, Fraemohs, Lietz, Weber (bib49) 2003; 17 Zhang, Wang, Gong, Mukaida, Young (bib50) 2001; 166 Jiang, Ting, Seed (bib20) 1998; 391 Nencioni, Lauber, Grünebach, Van Parijs, Denzlinger, Wesselborg (bib31) 2003; 171 Bidinger, Torres, Rossetti, Brown, Beltre, Burstein (bib3) 2003; 108 Chen, Chang, Tsi, Lin (bib8) 2003; 171 Meade, McIntyre, Zimmerman, Prescott (bib28) 1999; 274 Gilroy, Colville-Nash, Willis, Chivers, Paul-Clark, Willoughby (bib16) 1999; 5 Burstein, Rosenfeld, Wittstruck (bib5) 1972; 176 Pillinger, Capodici, Rosenthal, Kheterpal, Hanft, Philips (bib37) 1998; 95 Ward, Dransfield, Murray, Farrow, Haslett, Rossi (bib48) 2002; 168 Fujimori, Kanaoka, Sakaguchi, Urade (bib15) 2000; 275 Karst, Salim, Burstein, Conrad, Hoy, Schneider (bib23) 2003; 290 O'Sullivan, Koopman, Gay (bib33) 1992; 12 Tsubouchi, Kawahito, Kohno, Inoue, Hla, Sano (bib46) 2001; 283 Lehmann, Jϋngel, Lehmann, Busse, Biskop, Saalbach (bib25) 2000; 15 Stebulis, Rossetti, Atez, Zurier (bib41) 2005; 32 Cuzzocrea, Wayman, Mazzon, Dugo, Paola, Serraino (bib10) 2002; 61 Cuzzocrea (10.1016/j.lfs.2008.09.004_bib10) 2002; 61 Ricote (10.1016/j.lfs.2008.09.004_bib38) 1998; 391 Karst (10.1016/j.lfs.2008.09.004_bib23) 2003; 290 Chawla (10.1016/j.lfs.2008.09.004_bib7) 2001; 7 Liu (10.1016/j.lfs.2008.09.004_bib26) 2003; 63 Jiang (10.1016/j.lfs.2008.09.004_bib20) 1998; 391 Tsubouchi (10.1016/j.lfs.2008.09.004_bib46) 2001; 283 Meade (10.1016/j.lfs.2008.09.004_bib28) 1999; 274 Stichtenoth (10.1016/j.lfs.2008.09.004_bib42) 2001; 167 Smith (10.1016/j.lfs.2008.09.004_bib40) 2000; 69 Lehmann (10.1016/j.lfs.2008.09.004_bib25) 2000; 15 Zurier (10.1016/j.lfs.2008.09.004_bib52) 2003; 65 Johnson (10.1016/j.lfs.2008.09.004_bib21) 2007; 100 Petrova (10.1016/j.lfs.2008.09.004_bib36) 1999; 96 Zernecke (10.1016/j.lfs.2008.09.004_bib49) 2003; 17 Burstein (10.1016/j.lfs.2008.09.004_bib5) 1972; 176 Gilroy (10.1016/j.lfs.2008.09.004_bib17) 2003; 17 Müller-Ladner (10.1016/j.lfs.2008.09.004_bib29) 1995; 38 Nencioni (10.1016/j.lfs.2008.09.004_bib31) 2003; 171 Burstein (10.1016/j.lfs.2008.09.004_bib6) 1992; 35 Maggi (10.1016/j.lfs.2008.09.004_bib27) 2000; 49 Bidinger (10.1016/j.lfs.2008.09.004_bib3) 2003; 108 Zhang (10.1016/j.lfs.2008.09.004_bib50) 2001; 166 Sumariwalla (10.1016/j.lfs.2008.09.004_bib44) 2004; 50 Straus (10.1016/j.lfs.2008.09.004_bib43) 2000; 97 Chen (10.1016/j.lfs.2008.09.004_bib8) 2003; 171 Tanaka (10.1016/j.lfs.2008.09.004_bib45) 1988; 15 Zurier (10.1016/j.lfs.2008.09.004_bib51) 1998; 41 Cheng (10.1016/j.lfs.2008.09.004_bib9) 2004; 279 Müller-Ladner (10.1016/j.lfs.2008.09.004_bib30) 1996; 149 Fahmi (10.1016/j.lfs.2008.09.004_bib12) 2002; 10 Bianchi (10.1016/j.lfs.2008.09.004_bib2) 2005; 7 Bingham (10.1016/j.lfs.2008.09.004_bib4) 2002; 65 Pillinger (10.1016/j.lfs.2008.09.004_bib37) 1998; 95 Forman (10.1016/j.lfs.2008.09.004_bib14) 1995; 83 Pasceri (10.1016/j.lfs.2008.09.004_bib34) 2000; 101 Dyson (10.1016/j.lfs.2008.09.004_bib11) 2005; 116 O'Sullivan (10.1016/j.lfs.2008.09.004_bib33) 1992; 12 Fujimori (10.1016/j.lfs.2008.09.004_bib15) 2000; 275 Jackson (10.1016/j.lfs.2008.09.004_bib19) 1999; 19 Vann (10.1016/j.lfs.2008.09.004_bib47) 2007; 320 O'Sullivan (10.1016/j.lfs.2008.09.004_bib32) 1985; 28 Kalajdzic (10.1016/j.lfs.2008.09.004_bib22) 2002; 46 Abramson (10.1016/j.lfs.2008.09.004_bib1) 1989; 7 Stebulis (10.1016/j.lfs.2008.09.004_bib41) 2005; 32 Gilroy (10.1016/j.lfs.2008.09.004_bib16) 1999; 5 Inoue (10.1016/j.lfs.2008.09.004_bib18) 2000; 275 Faour (10.1016/j.lfs.2008.09.004_bib13) 2001; 276 Perez-Sala (10.1016/j.lfs.2008.09.004_bib35) 2003; 278 Kawahito (10.1016/j.lfs.2008.09.004_bib24) 2000; 106 Robinson (10.1016/j.lfs.2008.09.004_bib39) 1986; 163 Ward (10.1016/j.lfs.2008.09.004_bib48) 2002; 168 |
References_xml | – volume: 163 start-page: 1509 year: 1986 end-page: 1517 ident: bib39 article-title: Cyclooxygenase blockade elevates leukotriene E4 production during acute anaphylaxis in sheep publication-title: The Journal of Experimental Medicine contributor: fullname: Lowenstein – volume: 391 start-page: 79 year: 1998 end-page: 82 ident: bib38 article-title: The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation publication-title: Nature contributor: fullname: Glass – volume: 108 start-page: 95 year: 2003 end-page: 102 ident: bib3 article-title: Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes publication-title: Clinical Immunology contributor: fullname: Burstein – volume: 279 start-page: 22057 year: 2004 end-page: 22065 ident: bib9 article-title: Activation of peroxisome proliferator-activated receptor γ inhibits interleukin-1β-induced membrane-associated prostaglandin E publication-title: The Journal of Biological Chemistry contributor: fullname: Farrajota – volume: 35 start-page: 3135 year: 1992 end-page: 3141 ident: bib6 article-title: Synthetic nonpsychotropic cannabinoids with potent antiinflammatory, analgesic, and leukocyte anti-adhesion properties publication-title: Journal of Medicinal Chemistry contributor: fullname: Doyle – volume: 46 start-page: 494 year: 2002 end-page: 506 ident: bib22 article-title: Nimesulide, a preferential cyclooxygenase inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts publication-title: Arthritis & Rheumatism contributor: fullname: Pelletier – volume: 7 start-page: R1325 year: 2005 end-page: R1337 ident: bib2 article-title: Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)γ agonists on membrane-associated prostaglandin E publication-title: Arthritis Research & Therapy contributor: fullname: Netter – volume: 176 start-page: 422 year: 1972 end-page: 424 ident: bib5 article-title: Isolation and characterization of two major urinary metabolites of Δ publication-title: Science contributor: fullname: Wittstruck – volume: 38 start-page: 1328 year: 1995 end-page: 1332 ident: bib29 article-title: Progressive joint destruction in a human immunodeficiency virus-infected patient with rheumatoid arthritis publication-title: Arthritis & Rheumatism contributor: fullname: Chatham – volume: 50 start-page: 985 year: 2004 end-page: 998 ident: bib44 article-title: A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with anti-inflammatory properties in murine collagen-induced arthritis publication-title: Arthritis & Rheumatism contributor: fullname: Feldmann – volume: 275 start-page: 28028 year: 2000 end-page: 28032 ident: bib18 article-title: Feedback control of cyclooxygenase-2 expression through PPARγ publication-title: The Journal of Biological Chemistry contributor: fullname: Umesono – volume: 17 start-page: 1099 year: 2003 end-page: 1101 ident: bib49 article-title: Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction publication-title: The FASEB Journal contributor: fullname: Weber – volume: 274 start-page: 8328 year: 1999 end-page: 8334 ident: bib28 article-title: Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells publication-title: The Journal of Biological Chemistry contributor: fullname: Prescott – volume: 19 start-page: 2094 year: 1999 end-page: 2104 ident: bib19 article-title: Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte–endothelial cell interaction publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology contributor: fullname: Law – volume: 106 start-page: 189 year: 2000 end-page: 197 ident: bib24 article-title: 15-Deoxy-Δ publication-title: The Journal of Clinical Investigation contributor: fullname: Inoue – volume: 95 start-page: 14540 year: 1998 end-page: 14545 ident: bib37 article-title: Modes of action of aspirin-like drugs: salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Philips – volume: 7 start-page: 48 year: 2001 end-page: 52 ident: bib7 article-title: PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation publication-title: Nature Medicine contributor: fullname: Evans – volume: 116 start-page: 129 year: 2005 end-page: 137 ident: bib11 article-title: Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat publication-title: Pain contributor: fullname: Groarke – volume: 276 start-page: 31720 year: 2001 end-page: 31731 ident: bib13 article-title: Prostaglandin E publication-title: The Journal of Biological Chemistry contributor: fullname: Mancini – volume: 7 start-page: S163 year: 1989 end-page: S170 ident: bib1 article-title: The mechanisms of action of nonsteroidal anti-inflammatory drugs publication-title: Clinical and Experimental Rheumatology contributor: fullname: Weissmann – volume: 17 start-page: 2269 year: 2003 end-page: 2271 ident: bib17 article-title: Inducible cyclooxygenase-derived 15-deoxy-Δ publication-title: The FASEB Journal contributor: fullname: Lawrence – volume: 12 start-page: 115 year: 1992 end-page: 120 ident: bib33 article-title: Scanning electron microscopic evaluation of the arthritis in MRL/lpr mice publication-title: Rheumatology International contributor: fullname: Gay – volume: 65 start-page: 649 year: 2003 end-page: 655 ident: bib52 article-title: Suppression of human monocyte interleukin-1β production by ajulemic acid, a nonpsychoactive cannabinoid publication-title: Biochemical Pharmacology contributor: fullname: Bidinger – volume: 15 start-page: 301 year: 2000 end-page: 313 ident: bib25 article-title: Grafting of fibroblasts isolated from the synovial membrane of rheumatoid arthritis (RA) patients induces chronic arthritis in SCID mice—a novel model for studying the arthritogenic potential of RA fibroblasts in vivo publication-title: Journal of Autoimmunity contributor: fullname: Saalbach – volume: 101 start-page: 235 year: 2000 end-page: 238 ident: bib34 article-title: Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators publication-title: Circulation contributor: fullname: Yeh – volume: 171 start-page: 979 year: 2003 end-page: 988 ident: bib8 article-title: Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway publication-title: Journal of Immunology contributor: fullname: Lin – volume: 171 start-page: 5148 year: 2003 end-page: 5156 ident: bib31 article-title: Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling publication-title: Journal of Immunology contributor: fullname: Wesselborg – volume: 65 start-page: 3 year: 2002 end-page: 9 ident: bib4 article-title: The pathogenesis of rheumatoid arthritis: pivotal cytokines involved in bone degradation and inflammation publication-title: The Journal of Rheumatology Supplement contributor: fullname: Bingham – volume: 61 start-page: 997 year: 2002 end-page: 1007 ident: bib10 article-title: The cyclopentenone prostaglandin 15-deoxy-Δ publication-title: Molecular Pharmacology contributor: fullname: Serraino – volume: 283 start-page: 750 year: 2001 end-page: 755 ident: bib46 article-title: Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Δ publication-title: Biochemical and Biophysical Research Communications contributor: fullname: Sano – volume: 149 start-page: 1607 year: 1996 end-page: 1615 ident: bib30 article-title: Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice publication-title: The American Journal of Pathology contributor: fullname: Gay – volume: 320 start-page: 678 year: 2007 end-page: 686 ident: bib47 article-title: Cannabimimetic properties of ajulemic acid publication-title: The Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Wiley – volume: 5 start-page: 698 year: 1999 end-page: 701 ident: bib16 article-title: Inducible cyclooxygenase may have anti-inflammatory properties publication-title: Nature Medicine contributor: fullname: Willoughby – volume: 278 start-page: 51251 year: 2003 end-page: 51260 ident: bib35 article-title: Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-delta 12,14 prostaglandin J2 publication-title: The Journal of Biological Chemistry contributor: fullname: Canada – volume: 41 start-page: 163 year: 1998 end-page: 170 ident: bib51 article-title: Dimethylheptyl-THC-11-oic acid: a nonpsychoactive antiinflammatory agent with a cannabinoid template structure publication-title: Arthritis & Rheumatism contributor: fullname: Burstein – volume: 97 start-page: 4844 year: 2000 end-page: 4849 ident: bib43 article-title: 15-Deoxy-Δ publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Hsiang – volume: 15 start-page: 10 year: 1988 end-page: 16 ident: bib45 article-title: Etiopathogenesis of rheumatoid arthritis-like disease in MRL/1 mice. II. Ultrastructural basis of joint destruction publication-title: The Journal of Rheumatology contributor: fullname: Gay – volume: 63 start-page: 983 year: 2003 end-page: 992 ident: bib26 article-title: Activation and binding of peroxisome proliferator-activated receptor γ by synthetic cannabinoid ajulemic acid publication-title: Molecular Pharmacology contributor: fullname: Chen – volume: 290 start-page: 1757 year: 2003 end-page: 1762 ident: bib23 article-title: Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain publication-title: JAMA contributor: fullname: Schneider – volume: 49 start-page: 346 year: 2000 end-page: 355 ident: bib27 article-title: Anti-inflammatory actions of 15-deoxy-delta 12,14 prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine induced inducible nitric oxide synthase expression publication-title: Diabetes contributor: fullname: Corbett – volume: 32 start-page: 301 year: 2005 end-page: 306 ident: bib41 article-title: Fibroblast-like synovial cells derived from synovial fluid publication-title: The Journal of Rheumatology contributor: fullname: Zurier – volume: 168 start-page: 6232 year: 2002 end-page: 6243 ident: bib48 article-title: Prostaglandin D publication-title: Journal of Immunology contributor: fullname: Rossi – volume: 69 start-page: 145 year: 2000 end-page: 182 ident: bib40 article-title: Cyclooxygenases: structural, cellular, and molecular biology publication-title: Annual Review of Biochemistry contributor: fullname: Garavito – volume: 100 start-page: 184 year: 2007 end-page: 190 ident: bib21 article-title: Suppression of fibroblast metalloproteinases by ajulemic acid, a nonpsychoactive cannabinoid acid publication-title: Journal of Cellular Biochemistry contributor: fullname: Zurier – volume: 28 start-page: 529 year: 1985 end-page: 536 ident: bib32 article-title: Etiopathogenesis of the rheumatoid arthritis-like disease in MRL/1 mice. I. The histomorphologic basis of joint destruction publication-title: Arthritis & Rheumatism contributor: fullname: Koopman – volume: 167 start-page: 469 year: 2001 end-page: 474 ident: bib42 article-title: Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells publication-title: Journal of Immunology contributor: fullname: Crofford – volume: 83 start-page: 803 year: 1995 end-page: 812 ident: bib14 article-title: 15-Deoxy-Δ publication-title: Cell contributor: fullname: Evans – volume: 166 start-page: 7104 year: 2001 end-page: 7111 ident: bib50 article-title: Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2 publication-title: Journal of Immunology contributor: fullname: Young – volume: 275 start-page: 40511 year: 2000 end-page: 40516 ident: bib15 article-title: Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryotic cells. Roles of the oct-1 element in the 5′-flanking region and the AP-2 element in the untranslated exon 1 publication-title: The Journal of Biological Chemistry contributor: fullname: Urade – volume: 10 start-page: 845 year: 2002 end-page: 848 ident: bib12 article-title: 15d-PGJ publication-title: Osteoarthritis and Cartilage contributor: fullname: Martel-Pelletier – volume: 391 start-page: 82 year: 1998 end-page: 86 ident: bib20 article-title: PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines publication-title: Nature contributor: fullname: Seed – volume: 96 start-page: 4668 year: 1999 end-page: 4673 ident: bib36 article-title: Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-delta 12,14 prostaglandin J2 publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Van Eldik – volume: 28 start-page: 529 issue: 5 year: 1985 ident: 10.1016/j.lfs.2008.09.004_bib32 article-title: Etiopathogenesis of the rheumatoid arthritis-like disease in MRL/1 mice. I. The histomorphologic basis of joint destruction publication-title: Arthritis & Rheumatism doi: 10.1002/art.1780280511 contributor: fullname: O'Sullivan – volume: 5 start-page: 698 issue: 6 year: 1999 ident: 10.1016/j.lfs.2008.09.004_bib16 article-title: Inducible cyclooxygenase may have anti-inflammatory properties publication-title: Nature Medicine doi: 10.1038/9550 contributor: fullname: Gilroy – volume: 283 start-page: 750 issue: 4 year: 2001 ident: 10.1016/j.lfs.2008.09.004_bib46 article-title: Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Δ12,14-prostaglandin J2 publication-title: Biochemical and Biophysical Research Communications doi: 10.1006/bbrc.2001.4847 contributor: fullname: Tsubouchi – volume: 274 start-page: 8328 issue: 12 year: 1999 ident: 10.1016/j.lfs.2008.09.004_bib28 article-title: Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells publication-title: The Journal of Biological Chemistry doi: 10.1074/jbc.274.12.8328 contributor: fullname: Meade – volume: 15 start-page: 301 issue: 3 year: 2000 ident: 10.1016/j.lfs.2008.09.004_bib25 article-title: Grafting of fibroblasts isolated from the synovial membrane of rheumatoid arthritis (RA) patients induces chronic arthritis in SCID mice—a novel model for studying the arthritogenic potential of RA fibroblasts in vivo publication-title: Journal of Autoimmunity doi: 10.1006/jaut.2000.0435 contributor: fullname: Lehmann – volume: 275 start-page: 28028 issue: 36 year: 2000 ident: 10.1016/j.lfs.2008.09.004_bib18 article-title: Feedback control of cyclooxygenase-2 expression through PPARγ publication-title: The Journal of Biological Chemistry doi: 10.1074/jbc.M001387200 contributor: fullname: Inoue – volume: 49 start-page: 346 issue: 3 year: 2000 ident: 10.1016/j.lfs.2008.09.004_bib27 article-title: Anti-inflammatory actions of 15-deoxy-delta 12,14 prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine induced inducible nitric oxide synthase expression publication-title: Diabetes doi: 10.2337/diabetes.49.3.346 contributor: fullname: Maggi – volume: 391 start-page: 79 issue: 6662 year: 1998 ident: 10.1016/j.lfs.2008.09.004_bib38 article-title: The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation publication-title: Nature doi: 10.1038/34178 contributor: fullname: Ricote – volume: 65 start-page: 3 year: 2002 ident: 10.1016/j.lfs.2008.09.004_bib4 article-title: The pathogenesis of rheumatoid arthritis: pivotal cytokines involved in bone degradation and inflammation publication-title: The Journal of Rheumatology Supplement contributor: fullname: Bingham – volume: 96 start-page: 4668 issue: 8 year: 1999 ident: 10.1016/j.lfs.2008.09.004_bib36 article-title: Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-delta 12,14 prostaglandin J2 publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.96.8.4668 contributor: fullname: Petrova – volume: 290 start-page: 1757 year: 2003 ident: 10.1016/j.lfs.2008.09.004_bib23 article-title: Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain publication-title: JAMA doi: 10.1001/jama.290.13.1757 contributor: fullname: Karst – volume: 35 start-page: 3135 issue: 17 year: 1992 ident: 10.1016/j.lfs.2008.09.004_bib6 article-title: Synthetic nonpsychotropic cannabinoids with potent antiinflammatory, analgesic, and leukocyte anti-adhesion properties publication-title: Journal of Medicinal Chemistry doi: 10.1021/jm00095a007 contributor: fullname: Burstein – volume: 149 start-page: 1607 issue: 5 year: 1996 ident: 10.1016/j.lfs.2008.09.004_bib30 article-title: Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice publication-title: The American Journal of Pathology contributor: fullname: Müller-Ladner – volume: 168 start-page: 6232 issue: 12 year: 2002 ident: 10.1016/j.lfs.2008.09.004_bib48 article-title: Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of IκBα degradation using a peroxisome proliferator-activated receptor-γ-independent mechanism publication-title: Journal of Immunology doi: 10.4049/jimmunol.168.12.6232 contributor: fullname: Ward – volume: 19 start-page: 2094 issue: 9 year: 1999 ident: 10.1016/j.lfs.2008.09.004_bib19 article-title: Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte–endothelial cell interaction publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.19.9.2094 contributor: fullname: Jackson – volume: 100 start-page: 184 issue: 1 year: 2007 ident: 10.1016/j.lfs.2008.09.004_bib21 article-title: Suppression of fibroblast metalloproteinases by ajulemic acid, a nonpsychoactive cannabinoid acid publication-title: Journal of Cellular Biochemistry doi: 10.1002/jcb.21046 contributor: fullname: Johnson – volume: 97 start-page: 4844 year: 2000 ident: 10.1016/j.lfs.2008.09.004_bib43 article-title: 15-Deoxy-Δ12,14-prostaglandin J2 inhibits multiple steps in the NFκB signaling pathway publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.97.9.4844 contributor: fullname: Straus – volume: 95 start-page: 14540 issue: 24 year: 1998 ident: 10.1016/j.lfs.2008.09.004_bib37 article-title: Modes of action of aspirin-like drugs: salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.95.24.14540 contributor: fullname: Pillinger – volume: 17 start-page: 1099 year: 2003 ident: 10.1016/j.lfs.2008.09.004_bib49 article-title: Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction publication-title: The FASEB Journal doi: 10.1096/fj.02-0485fje contributor: fullname: Zernecke – volume: 69 start-page: 145 year: 2000 ident: 10.1016/j.lfs.2008.09.004_bib40 article-title: Cyclooxygenases: structural, cellular, and molecular biology publication-title: Annual Review of Biochemistry doi: 10.1146/annurev.biochem.69.1.145 contributor: fullname: Smith – volume: 278 start-page: 51251 issue: 51 year: 2003 ident: 10.1016/j.lfs.2008.09.004_bib35 article-title: Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-delta 12,14 prostaglandin J2 publication-title: The Journal of Biological Chemistry doi: 10.1074/jbc.M309409200 contributor: fullname: Perez-Sala – volume: 7 start-page: 48 issue: 1 year: 2001 ident: 10.1016/j.lfs.2008.09.004_bib7 article-title: PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation publication-title: Nature Medicine doi: 10.1038/83336 contributor: fullname: Chawla – volume: 391 start-page: 82 issue: 6662 year: 1998 ident: 10.1016/j.lfs.2008.09.004_bib20 article-title: PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines publication-title: Nature doi: 10.1038/34184 contributor: fullname: Jiang – volume: 46 start-page: 494 issue: 2 year: 2002 ident: 10.1016/j.lfs.2008.09.004_bib22 article-title: Nimesulide, a preferential cyclooxygenase inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts publication-title: Arthritis & Rheumatism doi: 10.1002/art.10055 contributor: fullname: Kalajdzic – volume: 171 start-page: 5148 issue: 10 year: 2003 ident: 10.1016/j.lfs.2008.09.004_bib31 article-title: Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling publication-title: Journal of Immunology doi: 10.4049/jimmunol.171.10.5148 contributor: fullname: Nencioni – volume: 10 start-page: 845 issue: 11 year: 2002 ident: 10.1016/j.lfs.2008.09.004_bib12 article-title: 15d-PGJ2 is acting as a ‘dual agent’ on the regulation of COX-2 expression in human osteoarthritis chondrocytes publication-title: Osteoarthritis and Cartilage doi: 10.1053/joca.2002.0835 contributor: fullname: Fahmi – volume: 176 start-page: 422 issue: 33 year: 1972 ident: 10.1016/j.lfs.2008.09.004_bib5 article-title: Isolation and characterization of two major urinary metabolites of Δ1-tetrahydrocannabinol publication-title: Science doi: 10.1126/science.176.4033.422 contributor: fullname: Burstein – volume: 101 start-page: 235 issue: 3 year: 2000 ident: 10.1016/j.lfs.2008.09.004_bib34 article-title: Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators publication-title: Circulation doi: 10.1161/01.CIR.101.3.235 contributor: fullname: Pasceri – volume: 61 start-page: 997 issue: 5 year: 2002 ident: 10.1016/j.lfs.2008.09.004_bib10 article-title: The cyclopentenone prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 attenuates the development of acute and chronic inflammation publication-title: Molecular Pharmacology doi: 10.1124/mol.61.5.997 contributor: fullname: Cuzzocrea – volume: 279 start-page: 22057 issue: 21 year: 2004 ident: 10.1016/j.lfs.2008.09.004_bib9 article-title: Activation of peroxisome proliferator-activated receptor γ inhibits interleukin-1β-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1 publication-title: The Journal of Biological Chemistry doi: 10.1074/jbc.M402828200 contributor: fullname: Cheng – volume: 41 start-page: 163 issue: 1 year: 1998 ident: 10.1016/j.lfs.2008.09.004_bib51 article-title: Dimethylheptyl-THC-11-oic acid: a nonpsychoactive antiinflammatory agent with a cannabinoid template structure publication-title: Arthritis & Rheumatism doi: 10.1002/1529-0131(199801)41:1<163::AID-ART20>3.0.CO;2-9 contributor: fullname: Zurier – volume: 50 start-page: 985 issue: 3 year: 2004 ident: 10.1016/j.lfs.2008.09.004_bib44 article-title: A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with anti-inflammatory properties in murine collagen-induced arthritis publication-title: Arthritis & Rheumatism doi: 10.1002/art.20050 contributor: fullname: Sumariwalla – volume: 108 start-page: 95 issue: 2 year: 2003 ident: 10.1016/j.lfs.2008.09.004_bib3 article-title: Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes publication-title: Clinical Immunology doi: 10.1016/S1521-6616(03)00064-0 contributor: fullname: Bidinger – volume: 275 start-page: 40511 issue: 51 year: 2000 ident: 10.1016/j.lfs.2008.09.004_bib15 article-title: Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryotic cells. Roles of the oct-1 element in the 5′-flanking region and the AP-2 element in the untranslated exon 1 publication-title: The Journal of Biological Chemistry doi: 10.1074/jbc.M007688200 contributor: fullname: Fujimori – volume: 12 start-page: 115 issue: 3 year: 1992 ident: 10.1016/j.lfs.2008.09.004_bib33 article-title: Scanning electron microscopic evaluation of the arthritis in MRL/lpr mice publication-title: Rheumatology International doi: 10.1007/BF00290266 contributor: fullname: O'Sullivan – volume: 106 start-page: 189 issue: 2 year: 2000 ident: 10.1016/j.lfs.2008.09.004_bib24 article-title: 15-Deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats publication-title: The Journal of Clinical Investigation doi: 10.1172/JCI9652 contributor: fullname: Kawahito – volume: 163 start-page: 1509 issue: 6 year: 1986 ident: 10.1016/j.lfs.2008.09.004_bib39 article-title: Cyclooxygenase blockade elevates leukotriene E4 production during acute anaphylaxis in sheep publication-title: The Journal of Experimental Medicine doi: 10.1084/jem.163.6.1509 contributor: fullname: Robinson – volume: 32 start-page: 301 issue: 2 year: 2005 ident: 10.1016/j.lfs.2008.09.004_bib41 article-title: Fibroblast-like synovial cells derived from synovial fluid publication-title: The Journal of Rheumatology contributor: fullname: Stebulis – volume: 65 start-page: 649 issue: 4 year: 2003 ident: 10.1016/j.lfs.2008.09.004_bib52 article-title: Suppression of human monocyte interleukin-1β production by ajulemic acid, a nonpsychoactive cannabinoid publication-title: Biochemical Pharmacology doi: 10.1016/S0006-2952(02)01604-0 contributor: fullname: Zurier – volume: 167 start-page: 469 issue: 1 year: 2001 ident: 10.1016/j.lfs.2008.09.004_bib42 article-title: Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells publication-title: Journal of Immunology doi: 10.4049/jimmunol.167.1.469 contributor: fullname: Stichtenoth – volume: 38 start-page: 1328 issue: 9 year: 1995 ident: 10.1016/j.lfs.2008.09.004_bib29 article-title: Progressive joint destruction in a human immunodeficiency virus-infected patient with rheumatoid arthritis publication-title: Arthritis & Rheumatism doi: 10.1002/art.1780380922 contributor: fullname: Müller-Ladner – volume: 83 start-page: 803 issue: 5 year: 1995 ident: 10.1016/j.lfs.2008.09.004_bib14 article-title: 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ publication-title: Cell doi: 10.1016/0092-8674(95)90193-0 contributor: fullname: Forman – volume: 17 start-page: 2269 issue: 15 year: 2003 ident: 10.1016/j.lfs.2008.09.004_bib17 article-title: Inducible cyclooxygenase-derived 15-deoxy-Δ12,14prostaglandin J2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis publication-title: The FASEB Journal doi: 10.1096/fj.02-1162fje contributor: fullname: Gilroy – volume: 15 start-page: 10 issue: 1 year: 1988 ident: 10.1016/j.lfs.2008.09.004_bib45 article-title: Etiopathogenesis of rheumatoid arthritis-like disease in MRL/1 mice. II. Ultrastructural basis of joint destruction publication-title: The Journal of Rheumatology contributor: fullname: Tanaka – volume: 320 start-page: 678 year: 2007 ident: 10.1016/j.lfs.2008.09.004_bib47 article-title: Cannabimimetic properties of ajulemic acid publication-title: The Journal of Pharmacology and Experimental Therapeutics doi: 10.1124/jpet.106.111625 contributor: fullname: Vann – volume: 7 start-page: R1325 issue: 6 year: 2005 ident: 10.1016/j.lfs.2008.09.004_bib2 article-title: Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)γ agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1β-stimulated rat chondrocytes: evidence for PPARγ-independent inhibition by 15-deoxy-Δ12,14prostaglandinJ2 publication-title: Arthritis Research & Therapy doi: 10.1186/ar1830 contributor: fullname: Bianchi – volume: 116 start-page: 129 year: 2005 ident: 10.1016/j.lfs.2008.09.004_bib11 article-title: Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat publication-title: Pain doi: 10.1016/j.pain.2005.03.037 contributor: fullname: Dyson – volume: 7 start-page: S163 issue: Suppl 3 year: 1989 ident: 10.1016/j.lfs.2008.09.004_bib1 article-title: The mechanisms of action of nonsteroidal anti-inflammatory drugs publication-title: Clinical and Experimental Rheumatology contributor: fullname: Abramson – volume: 63 start-page: 983 issue: 5 year: 2003 ident: 10.1016/j.lfs.2008.09.004_bib26 article-title: Activation and binding of peroxisome proliferator-activated receptor γ by synthetic cannabinoid ajulemic acid publication-title: Molecular Pharmacology doi: 10.1124/mol.63.5.983 contributor: fullname: Liu – volume: 166 start-page: 7104 issue: 12 year: 2001 ident: 10.1016/j.lfs.2008.09.004_bib50 article-title: Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2 publication-title: Journal of Immunology doi: 10.4049/jimmunol.166.12.7104 contributor: fullname: Zhang – volume: 276 start-page: 31720 issue: 34 year: 2001 ident: 10.1016/j.lfs.2008.09.004_bib13 article-title: Prostaglandin E2 regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1β-treated human synovial fibroblasts publication-title: The Journal of Biological Chemistry doi: 10.1074/jbc.M104036200 contributor: fullname: Faour – volume: 171 start-page: 979 issue: 2 year: 2003 ident: 10.1016/j.lfs.2008.09.004_bib8 article-title: Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway publication-title: Journal of Immunology doi: 10.4049/jimmunol.171.2.979 contributor: fullname: Chen |
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SubjectTerms | Anti-Inflammatory Agents Arachidonic Acid - biosynthesis Arthritis, Psoriatic - pathology Arthritis, Rheumatoid - pathology Cannabinoids Cyclooxygenase 2 Cyclooxygenase 2 - biosynthesis Dronabinol - analogs & derivatives Dronabinol - pharmacology Eicosanoids - metabolism Humans Inflammation Prostaglandins Prostaglandins - biosynthesis RNA, Messenger - biosynthesis RNA, Messenger - genetics Synovial cells Synovial Fluid - cytology Synovial Fluid - drug effects Synovial Fluid - metabolism Synovial Membrane - cytology Synovial Membrane - drug effects Synovial Membrane - metabolism |
Title | Ajulemic acid, a synthetic cannabinoid acid, induces an antiinflammatory profile of eicosanoids in human synovial cells |
URI | https://dx.doi.org/10.1016/j.lfs.2008.09.004 https://www.ncbi.nlm.nih.gov/pubmed/18840450 https://search.proquest.com/docview/69880034 |
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