In vivo native fluorescence spectroscopy and nicotinamide adinine dinucleotide/flavin adenine dinucleotide reduction and oxidation states of oral submucous fibrosis for chemopreventive drug monitoring

• Published in: Journal of biomedical optics Vol. 15; no. 1; p. 17010
• Main Authors: Sivabalan, Shanmugam, Vedeswari, C. Ponranjini, Jayachandran, Sadaksharam, Koteeswaran, Dornadula, Pravda, Chidambaranathan, Aruna, Prakasa Rao, Ganesan, Singaravelu
• Format: Journal Article
• Language: English
• Published: United States 01.01.2010
• Subjects: Adult; Areca; Dexamethasone - analogs & derivatives; Dexamethasone - therapeutic use; Discriminant Analysis; Drug Monitoring; Female; Flavin-Adenine Dinucleotide - chemistry; Flavin-Adenine Dinucleotide - metabolism; Humans; Hyaluronoglucosaminidase - therapeutic use; Male; NAD - chemistry; NAD - metabolism; Oral Submucous Fibrosis - drug therapy; Oral Submucous Fibrosis - metabolism; Oral Submucous Fibrosis - pathology; Oxidation-Reduction; Spectrometry, Fluorescence - methods; Tongue - metabolism

Native fluorescence spectroscopy has shown potential to characterize and diagnose oral malignancy. We aim at extending the native fluorescence spectroscopy technique to characterize normal and oral submucous fibrosis (OSF) patients under pre- and post-treated conditions, and verify whether this meth...