Emicizumab promotes factor Xa generation on endothelial cells

• Published in: Journal of thrombosis and haemostasis Vol. 22; no. 6; pp. 1605 - 1615
• Main Authors: Fager, Ammon M., Ellsworth, Patrick, Key, Nigel S., Monroe, Dougald M., Hoffman, Maureane
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.06.2024
• Subjects: coagulation; emicizumab; endothelium; factor IXa; factor VIIIa; hemophilia; emicizumab; endothelium; hemophilia; factor IXa; coagulation; factor VIIIa

Until recently, the treatment of hemophilia A relied on factor (F)VIII replacement. However, up to one-third of patients with severe hemophilia A develop neutralizing alloantibodies that render replacement therapies ineffective. The development of emicizumab, a bispecific antibody that partially mim...