The effects of plasma exchange and glucocorticoids on early kidney function among patients with ANCA-associated vasculitis in the PEXIVAS trial

• Published in: Kidney international Vol. 107; no. 3; pp. 558 - 567
• Main Authors: Uchida, Lisa, Pusey, Charles D., Jayne, David R.W., Walters, Giles, Jardine, Meg, Perkovic, Vlado, Cass, Alan, Summers, Shaun, Kerr, Peter, Noble, Euan, Johnson, David W., Peh, Chen Au, Jeffs, Lisa, Langham, Robyn, Reidlinger, Donna, Paul-Brent, Peta-Anne, Blockmans, Daniel, Henckaerts, Liesbet, Sprangers, Ben, Suri, Rita, Carette, Simon, Pagnoux, Christian, Walsh, Michael, Khalidi, Nader, Perl, Jeffrey, Copland, Michael, Fairhead, Todd, Habib, Syed, Gregersen, Jon, Bech, Jesper Nørgaard, Bataille, Pierre, Chantrel, François, Quémeneur, Thomas, Zaoui, Philippe, Le Jeune, Mathilde, Ficheux, Maxence, Aniort, Julien, Becmeur, Camille, Betz, Valérie, Seror, Raphaele, Coustet, Baptiste, Palazzo, Elisabeth, Ottaviani, Sébastien, Lebas, Céline, Mouthon, Luc, Ruivard, Marc, Limal, Nicolas, Maurier, François, Bachmeyer, Claude, Lega, Jean-Christophe, Andrès, Emmanuel, Buzio, Carlo, Kakita, Hiroko, Suzuki, Hiroyuki, Kono, Hajime, Nanki, Toshihiro, Asako, Kurumi, Yamagata, Kunihiro, Usui, Joichi, Sato, Yuji, Flores-Suárez, Luis Felipe, Sánchez-Guerrero, Sergio A., Collins, Michael, Schollum, John, Koldingsnes, Wenche, Nowak, Ilona, Gorka, Jacek, Bruchfeld, Annette, Fluck, Nicholas, McClure, Mark, Crump, Paul, Feilbach, Annika, Hilken, Nick, Hughes, Terry, Mehta, Samir, Levy, Jeremy, Doulton, Timothy, Barratt, Jonathon, Baines, Richard, Brunskill, Nigel, Hewins, Peter, Floßmann, Oliver, Haigh, Richard, Burns, Aine, Dhaygude, Ajay, Oliveira, David, Dunn, Emma, Lewington, Andrew J.P., Fan, Stanley Linsun, Yaqoob, Magdi, Quillen, Karen, Weisman, Michael, Specks, Ulrich, Warrington, Kenneth, Peikert, Tobias, Baqir, Misbah, Detwiler, Randy, Mottl, Amy, McGregor, JulieAnne, Kiss, Joseph
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2025
• Subjects: Adult; Aged; ANCA; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - therapy; end-stage kidney disease; Female; Glomerular Filtration Rate - drug effects; glomerulonephritis; Glomerulonephritis - immunology; Glomerulonephritis - physiopathology; Glomerulonephritis - therapy; Glucocorticoids - administration & dosage; Glucocorticoids - adverse effects; Glucocorticoids - therapeutic use; Humans; Kidney - drug effects; Kidney - physiopathology; kidney function; Male; Middle Aged; plasma exchange; Plasma Exchange - adverse effects; Recovery of Function; Time Factors; Treatment Outcome; vasculitis; end-stage kidney disease; kidney function; glomerulonephritis; plasma exchange; ANCA; vasculitis

Therapeutic plasma exchange (PLEX) is an adjunctive treatment for patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and kidney involvement. Little is known about the effect of PLEX on early changes in kidney function. This post-hoc analysis of the PEXIVAS trial investig...