High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet

• Published in: The journal of clinical endocrinology and metabolism Vol. 97; no. 12; pp. E2288 - E2292
• Main Authors: Silbernagel, Günther, Kovarova, Marketa, Cegan, Alexander, Machann, Jürgen, Schick, Fritz, Lehmann, Rainer, Häring, Hans-Ulrich, Stefan, Norbert, Schleicher, Erwin, Fritsche, Andreas, Peter, Andreas
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.12.2012
• Subjects: Adult; Body mass index; Desaturase; Diet, Atherogenic; Dietary Carbohydrates - administration & dosage; Dietary Carbohydrates - pharmacology; Dietary Fats - administration & dosage; Dietary Fats - pharmacology; Dietary supplements; Enzyme Activation - drug effects; Fatty acids; Fatty liver; Female; Health; High fat diet; Humans; Individuality; Lipid Metabolism - drug effects; Lipid Metabolism - physiology; Lipogenesis; Lipogenesis - drug effects; Lipogenesis - physiology; Lipoproteins, VLDL - blood; Lipoproteins, VLDL - metabolism; Liver; Liver - drug effects; Liver - enzymology; Liver - metabolism; Low fat diet; Magnetic resonance spectroscopy; Male; Monosaccharides; Nutrient deficiency; Stearoyl-CoA desaturase; Stearoyl-CoA Desaturase - metabolism; Steatosis; Sugar; Triglycerides; Triglycerides - blood; Triglycerides - metabolism

Context:Increased hepatic de novo lipogenesis (DNL) in response to dietary sugar is implicated in the pathophysiology of fatty liver. Saturated fatty acids are the product of DNL and exert lipotoxic effects that promote liver fat accumulation. Desaturation of fatty acids by stearoyl-CoA desaturase 1...