Gonadal steroids in critical illness

• Published in: Critical care clinics Vol. 22; no. 1; p. 87
• Main Authors: Mechanick, Jeffrey I, Nierman, David M
• Format: Journal Article
• Language: English
• Published: United States 01.01.2006
• Subjects: Androgens - physiology; Androgens - therapeutic use; Animals; Critical Illness; Estrogens - physiology; Estrogens - therapeutic use; Female; Gonadal Steroid Hormones - physiology; Gonadal Steroid Hormones - therapeutic use; Humans; Hypothalamo-Hypophyseal System - physiopathology; Male; Sex Factors; Stress, Physiological - drug therapy; Stress, Physiological - physiopathology

Gonadal steroids are metabolized in target cells and then interact with specific receptors to exert genomic and nongenomic effects. Complex feedback loops that involve the immune-neuroendocrine axis, limbic system, and gonadal steroids play a vital role in the adaptation to critical illness. Preclin...