Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: A promising therapeutic and prophylactic treatment for viral respiratory infections

•The novelty of this paper is shown by bringing new strategies to prophylaxis and alternative treatment for viral infections of the respiratory tract.•Overcome limitations related to the use of natural compounds through new pharmaceutical strategies as the development nanoemulsion with co-encapsulat...

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Published inEuropean journal of pharmaceutical sciences Vol. 197; p. 106766
Main Authors Vaiss, Daniela Pastorim, Rodrigues, Jamile Lima, Yurgel, Virginia Campello, do Carmo Guedes, Frank, da Matta, Lauanda Larissa Mendonça, Barros, Paula Alice Bezerra, Vaz, Gustavo Richter, dos Santos, Raíssa Nunes, Matte, Bibiana Franzen, Kupski, Larine, Garda-Buffon, Jaqueline, Bidone, Juliana, Muccillo-Baisch, Ana Luiza, Sonvico, Fabio, Dora, Cristiana Lima
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2024
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Abstract •The novelty of this paper is shown by bringing new strategies to prophylaxis and alternative treatment for viral infections of the respiratory tract.•Overcome limitations related to the use of natural compounds through new pharmaceutical strategies as the development nanoemulsion with co-encapsulated two compounds.•Evaluate the potential for local release of curcumin and quercetin from nanoemulsions in porcine nasal mucosa.•Evaluation of antiviral activity of nanoemulsions containing curcumin and quercetin against a murine β-coronavirus. One of the most frequent causes of respiratory infections are viruses. Viruses reaching the airways can be absorbed by the human body through the respiratory mucosa and mainly infect lung cells. Several viral infections are not yet curable, such as coronavirus-2 (SARS-CoV-2). Furthermore, the side effect of synthetic antiviral drugs and reduced efficacy against resistant variants have reinforced the search for alternative and effective treatment options, such as plant-derived antiviral molecules. Curcumin (CUR) and quercetin (QUE) are two natural compounds that have been widely studied for their health benefits, such as antiviral and anti-inflammatory activity. However, poor oral bioavailability limits the clinical applications of these natural compounds. In this work, nanoemulsions (NE) co-encapsulating CUR and QUE designed for nasal administration were developed as promising prophylactic and therapeutic treatments for viral respiratory infections. The NEs were prepared by high-pressure homogenization combined with the phase inversion temperature technique and evaluated for their physical and chemical characteristics. In vitro assays were performed to evaluate the nanoemulsion retention into the porcine nasal mucosa. In addition, the CUR and QUE-loaded NE antiviral activity was tested against a murine β-COV, namely MHV-3. The results evidenced that CUR and QUE loaded NE had a particle size of 400 nm and retention in the porcine nasal mucosa. The antiviral activity of the NEs showed a percentage of inhibition of around 99 %, indicating that the developed NEs has interesting properties as a therapeutic and prophylactic treatment against viral respiratory infections. [Display omitted]
AbstractList •The novelty of this paper is shown by bringing new strategies to prophylaxis and alternative treatment for viral infections of the respiratory tract.•Overcome limitations related to the use of natural compounds through new pharmaceutical strategies as the development nanoemulsion with co-encapsulated two compounds.•Evaluate the potential for local release of curcumin and quercetin from nanoemulsions in porcine nasal mucosa.•Evaluation of antiviral activity of nanoemulsions containing curcumin and quercetin against a murine β-coronavirus. One of the most frequent causes of respiratory infections are viruses. Viruses reaching the airways can be absorbed by the human body through the respiratory mucosa and mainly infect lung cells. Several viral infections are not yet curable, such as coronavirus-2 (SARS-CoV-2). Furthermore, the side effect of synthetic antiviral drugs and reduced efficacy against resistant variants have reinforced the search for alternative and effective treatment options, such as plant-derived antiviral molecules. Curcumin (CUR) and quercetin (QUE) are two natural compounds that have been widely studied for their health benefits, such as antiviral and anti-inflammatory activity. However, poor oral bioavailability limits the clinical applications of these natural compounds. In this work, nanoemulsions (NE) co-encapsulating CUR and QUE designed for nasal administration were developed as promising prophylactic and therapeutic treatments for viral respiratory infections. The NEs were prepared by high-pressure homogenization combined with the phase inversion temperature technique and evaluated for their physical and chemical characteristics. In vitro assays were performed to evaluate the nanoemulsion retention into the porcine nasal mucosa. In addition, the CUR and QUE-loaded NE antiviral activity was tested against a murine β-COV, namely MHV-3. The results evidenced that CUR and QUE loaded NE had a particle size of 400 nm and retention in the porcine nasal mucosa. The antiviral activity of the NEs showed a percentage of inhibition of around 99 %, indicating that the developed NEs has interesting properties as a therapeutic and prophylactic treatment against viral respiratory infections. [Display omitted]
One of the most frequent causes of respiratory infections are viruses. Viruses reaching the airways can be absorbed by the human body through the respiratory mucosa and mainly infect lung cells. Several viral infections are not yet curable, such as coronavirus-2 (SARS-CoV-2). Furthermore, the side effect of synthetic antiviral drugs and reduced efficacy against resistant variants have reinforced the search for alternative and effective treatment options, such as plant-derived antiviral molecules. Curcumin (CUR) and quercetin (QUE) are two natural compounds that have been widely studied for their health benefits, such as antiviral and anti-inflammatory activity. However, poor oral bioavailability limits the clinical applications of these natural compounds. In this work, nanoemulsions (NE) co-encapsulating CUR and QUE designed for nasal administration were developed as promising prophylactic and therapeutic treatments for viral respiratory infections. The NEs were prepared by high-pressure homogenization combined with the phase inversion temperature technique and evaluated for their physical and chemical characteristics. In vitro assays were performed to evaluate the nanoemulsion retention into the porcine nasal mucosa. In addition, the CUR and QUE-loaded NE antiviral activity was tested against a murine β-COV, namely MHV-3. The results evidenced that CUR and QUE loaded NE had a particle size of 400 nm and retention in the porcine nasal mucosa. The antiviral activity of the NEs showed a percentage of inhibition of around 99 %, indicating that the developed NEs has interesting properties as a therapeutic and prophylactic treatment against viral respiratory infections.
ArticleNumber 106766
Author Rodrigues, Jamile Lima
dos Santos, Raíssa Nunes
Vaiss, Daniela Pastorim
Dora, Cristiana Lima
da Matta, Lauanda Larissa Mendonça
Sonvico, Fabio
Kupski, Larine
Barros, Paula Alice Bezerra
Bidone, Juliana
Muccillo-Baisch, Ana Luiza
Matte, Bibiana Franzen
Vaz, Gustavo Richter
Garda-Buffon, Jaqueline
Yurgel, Virginia Campello
do Carmo Guedes, Frank
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  fullname: Rodrigues, Jamile Lima
  organization: Graduate Program in Food Science and Engineering, Federal University of Rio Grande, Rio Grande 96203-900 Brazil, RS, Brazil
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  givenname: Virginia Campello
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  givenname: Raíssa Nunes
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  fullname: dos Santos, Raíssa Nunes
  organization: Virology Laboratory of the Biotechnology Startup Núcleo Vitro, Porto Alegre 91040-600, Brazil
– sequence: 9
  givenname: Bibiana Franzen
  surname: Matte
  fullname: Matte, Bibiana Franzen
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  givenname: Larine
  surname: Kupski
  fullname: Kupski, Larine
  organization: Laboratory for Mycotoxins and Food Science, School of Chemistry and Food, Federal University of Rio Grande – FURG, Italy Avenue 8 km, Campus Carreiros, 96203-900 Rio Grande, RS, Brazil
– sequence: 11
  givenname: Jaqueline
  surname: Garda-Buffon
  fullname: Garda-Buffon, Jaqueline
  organization: Laboratory for Mycotoxins and Food Science, School of Chemistry and Food, Federal University of Rio Grande – FURG, Italy Avenue 8 km, Campus Carreiros, 96203-900 Rio Grande, RS, Brazil
– sequence: 12
  givenname: Juliana
  surname: Bidone
  fullname: Bidone, Juliana
  organization: Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Campus Capão do Leão, 96010-610 Pelotas, RS, Brazil
– sequence: 13
  givenname: Ana Luiza
  surname: Muccillo-Baisch
  fullname: Muccillo-Baisch, Ana Luiza
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  givenname: Fabio
  orcidid: 0000-0001-7372-1456
  surname: Sonvico
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  organization: Food and Drug Department, University of Parma, Parma, Italy
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  givenname: Cristiana Lima
  surname: Dora
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  email: cristianadora@gmail.com
  organization: Postgraduate Program in Health Sciences, Federal University of Rio Grande, Rio Grande 96203-900, Brazil
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Keywords SARS-CoV2
Antiviral natural compounds
Co-encapsulation
Curcumin
Quercetin
quercetin
antiviral natural compounds
co-encapsulation
curcumin
Language English
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Snippet •The novelty of this paper is shown by bringing new strategies to prophylaxis and alternative treatment for viral infections of the respiratory tract.•Overcome...
One of the most frequent causes of respiratory infections are viruses. Viruses reaching the airways can be absorbed by the human body through the respiratory...
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StartPage 106766
SubjectTerms Antiviral natural compounds
Co-encapsulation
Curcumin
Quercetin
SARS-CoV2
Title Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: A promising therapeutic and prophylactic treatment for viral respiratory infections
URI https://dx.doi.org/10.1016/j.ejps.2024.106766
https://www.ncbi.nlm.nih.gov/pubmed/38615970
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