Effect of protein binding on the pharmacokinetics of the six substrates in the Basel phenotyping cocktail in healthy subjects and patients with liver cirrhosis

• Published in: European journal of pharmaceutical sciences Vol. 202; p. 106885
• Main Authors: Duthaler, Urs, Chapuisat, Fabio, Hanimann, Robin, Krähenbühl, Stephan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2024
• Subjects: Basel phenotyping cocktail; CYP1A2; CYP2B6; CYP2C19; CYP2C9; CYP2D6; CYP3A4; Protein binding; Basel phenotyping cocktail; CYP2C9; CYP2B6; CYP2D6; CYP1A2; CYP2C19; CYP3A4; Protein binding

•In control subjects and patients with liver cirrhosis, the metabolic ratios (MR) calculated with total or free drug concentrations correlated well for probe drugs with protein binding ≤99 %.•CYP activity was predicted well by the MR calculated with free or total concentrations of probe drugs with p...