The impact of topical capsaicin application on the muscle metaboreflex and microvascular responsiveness

• Published in: Physiological reports Vol. 13; no. 15; pp. e70496 - n/a
• Main Authors: Carpenter, Nikolaus D., Wahl, Aaron E., Butenas, Alec L. E., Toribio, Sherwin, Caldwell, Jacob T.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2025; John Wiley and Sons Inc; Wiley
• Subjects: Administration, Topical; Adult; Blood pressure; Blood Pressure - drug effects; Capsaicin; Capsaicin - administration & dosage; Capsaicin - pharmacology; Cardiovascular disease; Exercise; Exercise - physiology; Female; Females; Gender differences; Hand Strength; Humans; Hyperemia; Infrared spectroscopy; Male; Males; Menstruation; Metabolism; Metabolites; metaboreflex; Microcirculation - drug effects; microvascular; Microvasculature; Microvessels - drug effects; Microvessels - physiology; Muscle, Skeletal - blood supply; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; near‐infrared spectroscopy; Nitric oxide; Original; Physical fitness; Reflex - drug effects; Regular Manuscript; Sensory System Agents - administration & dosage; Spectrum analysis; Young Adult; microvascular; near‐infrared spectroscopy; capsaicin; metaboreflex

Topical capsaicin reduces metaboreflex responses during post‐exercise circulatory arrest (PECA) in males, but its effects in females and on microvascular responsiveness in either sex remain unclear. This study hypothesized that capsaicin would reduce blood pressure during PECA in males but not femal...