Difficulties in taking aminosalicylates for patients with ulcerative colitis

Aminosalicylates are effective in inducing remission and are also useful in preventing relapse of ulcerative colitis (UC); however, previous studies have reported a 30%-45% rate of nonadherence to prescribed medication among UC patients. Enumerating and conceptualizing the difficulties in taking ami...

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Published inGastroenterology nursing Vol. 35; no. 1; p. 24
Main Authors Kawakami, Aki, Tanaka, Makoto, Ochiai, Ryota, Naganuma, Makoto, Iwao, Yasushi, Hibi, Toshifumi, Kazuma, Keiko
Format Journal Article
LanguageEnglish
Published United States 01.01.2012
Subjects
Adult
Aged
Aminosalicylic Acids - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Cohort Studies
Colitis, Ulcerative - drug therapy
Female
Health Services Accessibility
Humans
Japan
Male
Mesalamine - therapeutic use
Middle Aged
Patient Acceptance of Health Care
Sulfasalazine - therapeutic use
Young Adult
Japan
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Abstract Aminosalicylates are effective in inducing remission and are also useful in preventing relapse of ulcerative colitis (UC); however, previous studies have reported a 30%-45% rate of nonadherence to prescribed medication among UC patients. Enumerating and conceptualizing the difficulties in taking aminosalicylates enable us to assess and support patients more effectively. The aim of this study was to investigate the difficulties in taking aminosalicylates among Japanese UC patients and explore factors related to these difficulties. Outpatients with UC (n = 242) completed a questionnaire supported by a semistructured interview on the basis of a literature review. Twelve items about difficulties in taking aminosalicylates were processed by factor analysis and the related factors regarding difficulties were analyzed. The following three independent domains were identified: Domain 1: diminished sense of priority for medication; Domain 2: concern about side effects; and Domain 3: burden of taking the prescribed drug. Factors related to the difficulties in taking aminosalicylates included the disease state, psychosocial factors, and demographic characteristic variables. On the basis of the results, we recommend the creation and validation of a program aimed at decreasing the difficulties in taking aminosalicylates.
AbstractList Aminosalicylates are effective in inducing remission and are also useful in preventing relapse of ulcerative colitis (UC); however, previous studies have reported a 30%-45% rate of nonadherence to prescribed medication among UC patients. Enumerating and conceptualizing the difficulties in taking aminosalicylates enable us to assess and support patients more effectively. The aim of this study was to investigate the difficulties in taking aminosalicylates among Japanese UC patients and explore factors related to these difficulties. Outpatients with UC (n = 242) completed a questionnaire supported by a semistructured interview on the basis of a literature review. Twelve items about difficulties in taking aminosalicylates were processed by factor analysis and the related factors regarding difficulties were analyzed. The following three independent domains were identified: Domain 1: diminished sense of priority for medication; Domain 2: concern about side effects; and Domain 3: burden of taking the prescribed drug. Factors related to the difficulties in taking aminosalicylates included the disease state, psychosocial factors, and demographic characteristic variables. On the basis of the results, we recommend the creation and validation of a program aimed at decreasing the difficulties in taking aminosalicylates.
Author Naganuma, Makoto
Kawakami, Aki
Ochiai, Ryota
Kazuma, Keiko
Hibi, Toshifumi
Tanaka, Makoto
Iwao, Yasushi
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Snippet Aminosalicylates are effective in inducing remission and are also useful in preventing relapse of ulcerative colitis (UC); however, previous studies have...
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StartPage 24
SubjectTerms Adult
Aged
Aminosalicylic Acids - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Cohort Studies
Colitis, Ulcerative - drug therapy
Female
Health Services Accessibility
Humans
Japan
Male
Mesalamine - therapeutic use
Middle Aged
Patient Acceptance of Health Care
Sulfasalazine - therapeutic use
Young Adult
Title Difficulties in taking aminosalicylates for patients with ulcerative colitis
URI https://www.ncbi.nlm.nih.gov/pubmed/22306727
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