m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development

• Published in: Immunity (Cambridge, Mass.) Vol. 52; no. 6; pp. 1007 - 1021.e8
• Main Authors: Gao, Yimeng, Vasic, Radovan, Song, Yuanbin, Teng, Rhea, Liu, Chengyang, Gbyli, Rana, Biancon, Giulia, Nelakanti, Raman, Lobben, Kirsten, Kudo, Eriko, Liu, Wei, Ardasheva, Anastasia, Fu, Xiaoying, Wang, Xiaman, Joshi, Poorval, Lee, Veronica, Dura, Burak, Viero, Gabriella, Iwasaki, Akiko, Fan, Rong, Xiao, Andrew, Flavell, Richard A., Li, Hua-Bing, Tebaldi, Toma, Halene, Stephanie
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.06.2020
• Subjects: double-stranded RNA; dsRNA; epitranscriptome; hematopoiesis; hematopoietic development; innate immune response; m6A; METTL3; N6-methyladenosine; RNA modification; dsRNA; RNA modification; hematopoietic development; hematopoiesis; innate immune response; METTL3; m6A; N6-methyladenosine; epitranscriptome; double-stranded RNA

N6-methyladenosine (m6A) is the most abundant RNA modification, but little is known about its role in mammalian hematopoietic development. Here, we show that conditional deletion of the m6A writer METTL3 in murine fetal liver resulted in hematopoietic failure and perinatal lethality. Loss of METTL3...