Associations of Circulating 25-Hydroxyvitamin D3 Concentrations With Incident, Sporadic Colorectal Adenoma Risk According to Common Vitamin D–Binding Protein Isoforms

• Published in: American journal of epidemiology Vol. 187; no. 9; pp. 1923 - 1930
• Main Authors: Gibbs, David C, Fedirko, Veronika, Um, Caroline, Gross, Myron D, Thyagarajan, Bharat, Bostick, Roberd M
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.09.2018; Oxford Publishing Limited (England)
• Subjects: 25-Hydroxyvitamin D; Adenoma; Adenoma - blood; Adenoma - genetics; Adult; Aged; Calcifediol - blood; Calciferol; Case-Control Studies; Colon; Colorectal cancer; Colorectal Neoplasms - blood; Colorectal Neoplasms - genetics; Confidence intervals; Female; Humans; Isoforms; Male; Middle Aged; Original Contributions; Protein Isoforms; Proteins; Risk; Statistical analysis; Tumors; Vitamin D; Vitamin D-binding protein; Vitamin D-Binding Protein - genetics; colorectal neoplasms; vitamin D; vitamin D–binding protein; gene-environment interaction; case-control studies

Abstract Concentration of 25-hydroxyvitamin D3 (25(OH)D3), the main circulating form of vitamin D, is inversely associated with incident, sporadic colorectal adenoma risk. We investigated whether this association differs by 2 functional variants in the vitamin D–binding protein (DBP) gene, group-spe...