Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy

• Published in: International journal of medical sciences Vol. 4; no. 1; pp. 1 - 6
• Main Authors: Goto, Yasuyuki, Ando, Takafumi, Nishio, Kazuko, Kawai, Sayo, Ishida, Yoshiko, Naito, Mariko, Goto, Hidemi, Hamajima, Nobuyuki
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher 2007
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adult; Aged; Aged, 80 and over; Atrophy; Female; Gastric Mucosa - pathology; Helicobacter Infections - etiology; Helicobacter Infections - genetics; Helicobacter pylori; Humans; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Male; Metaplasia; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases - genetics; Protein Tyrosine Phosphatases - metabolism; Research Paper; Risk Factors; SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; Stomach Neoplasms - etiology

Various single nucleotide polymorphisms (SNPs) have explained the association between Helicobacter pylori (H. pylori) and gastric atrophy and cancer. This study investigated the associations of Grb2 associated binder 1 (Gab1) polymorphism and the combination of PTPN11 gene encoding src homology 2 do...