Alphafetoprotein-producing gastric adenocarcinoma

• Published in: Histopathology Vol. 26; no. 2; p. 171
• Main Authors: Petrella, T, Montagnon, J, Roignot, P, Van Nieuvanhuyse, A, Matagrin, C, Michiels-Marzais, D, Dusserre-Guion, L, Spiekermann, C
• Format: Journal Article
• Language: English
• Published: England 01.02.1995
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Aged; Aged, 80 and over; alpha-Fetoproteins - biosynthesis; DNA, Neoplasm - analysis; Humans; Immunohistochemistry; Male; Ploidies; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism
• DOI: 10.1111/j.1365-2559.1995.tb00648.x
• ISSN: 0309-0167

We report a rare gastric tumour characterized morphologically by its hepatoid features and alpha-fetoprotein production and which presented clinically with gastric haemorrhage. Gastric fibroscopy showed a bleeding tumour of the antrum. The microscopic appearance of the tumor showed two different patterns. The most extensive presented hepatoid features. The second pattern showed undifferentiated features. The tumour cells showed immunohistochemical positivity for alphafetoprotein, EMA and p53 protein; 37% were aneuploid with a DNA index of 1.46. The serum level of alphafetoprotein was not measured before the gastrectomy but after ten days it was elevated at 1070 ng/ml. The patient died 6 months after the admission. This case provides, for the first time, information on the DNA content and the p53 expression of this unusual and aggressive variant of gastric adenocarcinoma.