Challenges of in situ hybridization in miRNA analysis of triple-negative breast cancer morphological diversity

• Published in: Neoplasma Vol. 70; no. 2; p. 179
• Main Authors: Kolečková, Markéta, Bezděková, Michala, Bouchal, Jan, Janíková, Mária, Bohošová, Júlia, Slabý, Ondřej, Svoboda, Marek, Srovnal, Josef, Vomáčková, Katherine, Überall, Ivo, Kolář, Zdeněk
• Format: Journal Article
• Language: English
• Published: Slovakia 01.04.2023
• Subjects: Humans; MicroRNAs - genetics; MicroRNAs - metabolism; Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - pathology

miRNA expression in triple-negative breast cancers (TNBC) has mainly been studied from a methodological viewpoint. However, it has not been considered that miRNA expression profile may be associated with a specific morphological entity inside every tumor. The verification of this hypothesis on a set...