A randomised trial of glucocorticoids in acute-stage allergic bronchopulmonary aspergillosis complicating asthma

• Published in: The European respiratory journal Vol. 47; no. 2; pp. 490 - 498
• Main Authors: Agarwal, Ritesh, Aggarwal, Ashutosh N., Dhooria, Sahajal, Singh Sehgal, Inderpaul, Garg, Mandeep, Saikia, Biman, Behera, Digambar, Chakrabarti, Arunaloke
• Format: Journal Article
• Language: English
• Published: England 01.02.2016
• Subjects: Acute Disease; Adult; Aspergillosis, Allergic Bronchopulmonary - complications; Aspergillosis, Allergic Bronchopulmonary - diagnostic imaging; Aspergillosis, Allergic Bronchopulmonary - drug therapy; Aspergillosis, Allergic Bronchopulmonary - physiopathology; Asthma - complications; Asthma - diagnostic imaging; Asthma - drug therapy; Asthma - physiopathology; Bronchiectasis - complications; Bronchiectasis - diagnostic imaging; Bronchiectasis - drug therapy; Bronchiectasis - physiopathology; Disease Progression; Female; Forced Expiratory Volume; Glucocorticoids - administration & dosage; Humans; Male; Prednisolone - administration & dosage; Severity of Illness Index; Tomography, X-Ray Computed; Treatment Outcome; Vital Capacity; Young Adult

Whether use of high-dose steroids in acute-stage allergic bronchopulmonary aspergillosis (ABPA) is associated with superior outcomes is not known. Herein, we compare the efficacy and safety of two glucocorticoid protocols in ABPA. Treatment-naive ABPA subjects randomly received either high-dose or m...