The self-assembled nanoparticle-based multi-epitope influenza mRNA vaccine elicits protective immunity against H1N1 and B influenza viruses in mice

• Published in: Frontiers in immunology Vol. 15; p. 1483720
• Main Authors: Di, Yaxin, Zhang, Chenchao, Ren, Zilin, Jiang, Renyue, Tang, Jiafeng, Yang, Songhui, Wang, Ziliang, Yu, Tong, Zhang, Tong, Yu, Ziping, Xu, Zhiqiang, Zhuang, Xinyu, Jin, Ningyi, Tian, Mingyao
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.10.2024
• Subjects: Animals; Antibodies, Viral - blood; Antibodies, Viral - immunology; Epitopes - immunology; Female; Humans; immunogenicity; Immunology; Influenza A Virus, H1N1 Subtype - immunology; Influenza B virus - immunology; Influenza Vaccines - immunology; influenza virus; Mice; Mice, Inbred C57BL; mRNA Vaccines; multivalent epitopes; nanoparticle; Nanoparticles; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - prevention & control; Viral Matrix Proteins - genetics; Viral Matrix Proteins - immunology; influenza virus; mRNA vaccines; nanoparticle; multivalent epitopes; immunogenicity

The influenza virus is recognized as the primary cause of human respiratory diseases, with the current influenza vaccine primarily offering strain-specific immunity and limited protection against drifting strains. Considering this, the development of a broad-spectrum influenza vaccine capable of ind...