Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout

• Published in: The European respiratory journal Vol. 52; no. 5; p. 1800821
• Main Authors: Smith, Laurie J., Collier, Guilhem J., Marshall, Helen, Hughes, Paul J.C., Biancardi, Alberto M., Wildman, Martin, Aldag, Ina, West, Noreen, Horsley, Alex, Wild, Jim M.
• Format: Journal Article
• Language: English
• Published: England 01.11.2018
• Subjects: Adolescent; Adult; Child; Cystic Fibrosis - diagnosis; Cystic Fibrosis - physiopathology; Female; Forced Expiratory Volume; Functional Residual Capacity; Humans; Lung - physiopathology; Magnetic Resonance Imaging; Male; Respiratory Function Tests - methods; Tidal Volume; Young Adult

Hyperpolarised helium-3 ( 3 He) ventilation magnetic resonance imaging (MRI) and multiple-breath washout (MBW) are sensitive methods for detecting lung disease in cystic fibrosis (CF). We aimed to explore their relationship across a broad range of CF disease severity and patient age, as well as asse...