Optimization of specific multiplex DNA primers to detect variable CLU genomic lesions in patients with Alzheimer’s disease

• Published in: Biochip journal Vol. 9; no. 4; pp. 278 - 284
• Main Authors: Van Giau, Vo, An, Seong Soo A.
• Format: Journal Article
• Language: English
• Published: Seoul The Korean BioChip Society (KBCS) 01.12.2015; Springer Nature B.V; 한국바이오칩학회
• Subjects: Alzheimer's disease; Apolipoproteins; Atherogenesis; Biomedical Engineering and Bioengineering; Biotechnology; Chemistry; Chemistry and Materials Science; Clusterin; DNA chips; DNA microarrays; Gene expression; Genetic diversity; Lipid metabolism; Lipids; Low frequency; Mutation; Neurodegenerative diseases; Nucleotides; Original Article; Polymerase chain reaction; Single-nucleotide polymorphism; Susceptibility; 생물공학; SNPs; variants; Alzheimer’s disease; DNA primers; Clusterin; PCR analysis

Recently, polymorphisms in the clusterin ( CLU ) or Apolipoprotein J (ApoJ) gene were reported to be involved in lipid metabolism, atherogenesis, and being associated with the risk of developing Alzheimer’s disease (AD). The influences from genetic variation has not been examined among Koreans. To s...