Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy

• Published in: Journal of the American Society of Nephrology Vol. 26; no. 5; pp. 1195 - 1204
• Main Authors: Zhu, Li, Zhai, Ya-Ling, Wang, Feng-Mei, Hou, Ping, Lv, Ji-Cheng, Xu, Da-Min, Shi, Su-Fang, Liu, Li-Jun, Yu, Feng, Zhao, Ming-Hui, Novak, Jan, Gharavi, Ali G., Zhang, Hong
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.05.2015
• Subjects: Adult; Alleles; Blood Proteins - genetics; Case-Control Studies; Clinical Research; Complement Activation; Complement C3a - metabolism; Complement C3b Inactivator Proteins - genetics; Complement Factor H - genetics; Complement Factor H - metabolism; Cross-Sectional Studies; Female; Glomerular Mesangium - metabolism; Glomerulonephritis, IGA - blood; Glomerulonephritis, IGA - genetics; Humans; Immunoglobulin A - blood; Male; Middle Aged; Polymorphism, Single Nucleotide; Young Adult; complement activation; IgA nephropathy; complement factor H receptor 3-1Δ deletion; complement factor H

Complement activation is common in patients with IgA nephropathy (IgAN) and associated with disease severity. Our recent genome-wide association study of IgAN identified susceptibility loci on 1q32 containing the complement regulatory protein-encoding genes CFH and CFHR1-5, with rs6677604 in CFH as...