Association of manganese superoxide dismutase and glutathione S-transferases genotypes with myocardial infarction in patients with type 2 diabetes mellitus

• Published in: Diabetes research and clinical practice Vol. 98; no. 1; pp. 144 - 150
• Main Authors: Kariž, Stojan, Nikolajević Starčević, Jovana, Petrovič, Daniel
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.10.2012
• Subjects: Alanine; Biomarkers - blood; Blood Glucose - metabolism; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetic Angiopathies - blood; Diabetic Angiopathies - epidemiology; Diabetic Angiopathies - genetics; Endocrinology & Metabolism; European Continental Ancestry Group; Female; Genetic Predisposition to Disease; Genotype; Glutathione S-transferase; Glutathione S-Transferase pi - blood; Glutathione Transferase - blood; Humans; Lipids - blood; Logistic Models; Male; Manganese superoxide dismutase; Middle Aged; Myocardial infarction; Myocardial Infarction - blood; Myocardial Infarction - epidemiology; Myocardial Infarction - genetics; Oxidative Stress; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Risk Factors; Slovenia - epidemiology; Superoxide Dismutase - blood; Type 2 diabetes mellitus; Valine; Slovenia; Myocardial infarction; Oxidative stress; Type 2 diabetes mellitus; Glutathione S-transferase; Manganese superoxide dismutase

Abstract Aim In the present study we investigated the association between genetic polymorphisms with functional effects on redox regulation: Val16Ala of manganese superoxide dismutase (MnSOD), polymorphic deletions of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and Ile105Val of glutathione...