Multigenetic pharmacogenomics–guided treatment shows greater improvements on motor symptoms compared to usual therapy in Parkinson’s disease: a small real-word prospective cohort study

• Published in: Frontiers in pharmacology Vol. 16; p. 1502379
• Main Authors: Li, Yifan, Li, Mao, Wang, Miao, Yao, Jiarui, Li, Fengzhu, Chen, Siyu, Yin, Xi, Gao, Zhongbao
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.03.2025
• Subjects: drug efficacy; Parkinson’s disease; personalized medicine; pharmacogenomics; Pharmacology; single nucleotide polymorphisms; drug efficacy; pharmacogenomics; single nucleotide polymorphisms; Parkinson’s disease; personalized medicine

Dopamine replacement therapy is a cornerstone of Parkinson's disease treatment. In clinical practice, there is considerable variability in patients' responses, tolerability, and safety regarding anti-parkinsonian medications, which is largely influenced by genetic polymorphisms in pharmaco...