Supranormal stimulation of deoxyribonucleic acid synthesis in FRTL5 cells by serum from patients with untreated acromegaly

• Published in: The journal of clinical endocrinology and metabolism Vol. 66; no. 6; p. 1227
• Main Authors: Misaki, T, Maciel, R M, Tramontano, D, Moses, A C, Lombardi, A, Ingbar, S H
• Format: Journal Article
• Language: English
• Published: United States 01.06.1988
• Subjects: Acromegaly - blood; Adult; Antibodies - physiology; Cell Line; DNA - biosynthesis; Female; Growth Hormone - blood; Growth Substances - blood; Growth Substances - physiology; Humans; Insulin-Like Growth Factor I - blood; Insulin-Like Growth Factor I - immunology; Male; Middle Aged; Mitosis; Osmolar Concentration; Thymidine - metabolism; Thyroid Gland - cytology; Thyroid Gland - metabolism

Insulin-like growth factor I (IGF-I) is one of a number of mitogenic factors in the serum of animals and humans. We demonstrated previously that IGF-I is a potent mitogen for FRTL5 cells, a line of rat thyroid follicular cells. In this study, we assessed the relevance of this finding with respect to...