Visualization of differential GPCR crosstalk in DRD1-DRD2 heterodimer upon different dopamine levels

• Published in: Progress in neurobiology Vol. 213; p. 102266
• Main Authors: Kim, Hyunbin, Nam, Min-Ho, Jeong, Sohyeon, Lee, Hyowon, Oh, Soo-Jin, Kim, Jeongjin, Choi, Nakwon, Seong, Jihye
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2022
• Subjects: Brain - metabolism; cAMP; Dopamine; Dopamine receptor sensor; DRD1; DRD2; GPCR heterodimer; Humans; Receptors, Dopamine D1 - metabolism; Receptors, Dopamine D2 - metabolism; Signal Transduction; Tonic and phasic DA release; DRD1; Tonic and phasic DA release; DRD2; cAMP; GPCR heterodimer; Dopamine receptor sensor

Dopaminergic signaling is regulated by transient micromolar (phasic) and background nanomolar (tonic) dopamine releases in the brain. These dopamine signals can be differentially translated by dopamine receptor type 1 and type 2, DRD1 and DRD2, which are G protein-coupled receptors (GPCRs). In respo...