The gut–kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity

• Published in: Frontiers in pharmacology Vol. 16; p. 1518481
• Main Authors: Han, Cong, Gao, Ran-ran, Zhou, Le, Li, Wei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.01.2025
• Subjects: astragaloside IV; cyclosporine-induced nephrotoxicity; LC-MS analysis; Pharmacology; sequencing of 16S rDNA; sequencing of lncRNAs and mRNAs; sequencing of 16S rDNA; cyclosporine-induced nephrotoxicity; sequencing of lncRNAs and mRNAs; LC-MS analysis; astragaloside IV

Chronic nephrotoxicity caused by CNIs (CICN) manifests clinically as chronic kidney disease (CKD). Astragaloside IV (AS-IV) plays a certain role in the treatment of CKD. This study aimed to verify the ameliorative effects of AS-IV on CICN and further explore the mechanisms underlying the modulation...