Human immunodeficiency virus type 1 Vpr polymorphisms associated with progressor and nonprogressor individuals alter Vpr-associated functions

• Published in: Journal of general virology Vol. 95; no. 3; pp. 700 - 711
• Main Authors: Hadi, Kevin, Walker, Leah A., Guha, Debjani, Murali, Ramachandran, Watkins, Simon C., Tarwater, Patrick, Srinivasan, Alagarsamy, Ayyavoo, Velpandi
• Format: Journal Article
• Language: English
• Published: England Society for General Microbiology 01.03.2014
• Subjects: Animal; Disease Progression; G2 Phase Cell Cycle Checkpoints; HIV Infections - pathology; HIV Infections - physiopathology; HIV Infections - virology; HIV-1 - classification; HIV-1 - genetics; HIV-1 - isolation & purification; HIV-1 - physiology; Humans; Phylogeny; Polymorphism, Genetic; Virus Replication; vpr Gene Products, Human Immunodeficiency Virus - genetics; vpr Gene Products, Human Immunodeficiency Virus - metabolism

Following infection with Human immunodeficiency virus 1 (HIV-1) there is a remarkable variation in virus replication and disease progression. Both host and viral factors have been implicated in the observed differences in disease status. Here, we focus on understanding the contribution of HIV-1 vira...