Staphylococcus aureus-specific TIGIT+ Treg are present in the blood of healthy subjects – a hurdle for vaccination?

• Published in: Frontiers in immunology Vol. 15; p. 1500696
• Main Authors: Clegg, Jonah, Mnich, Malgorzata E., Carignano, Alberto, Cova, Giovanni, Tavarini, Simona, Sammicheli, Chiara, Clemente, Bruna, Smith, Megan, Siena, Emilio, Bardelli, Monia, Brazzoli, Michela, Bagnoli, Fabio, McLoughlin, Rachel M., Soldaini, Elisabetta
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.02.2025
• Subjects: Adult; Cytokines; Female; Healthy Volunteers; host-pathogen interactions; Humans; Immunology; Male; Receptors, Immunologic - immunology; Receptors, Immunologic - metabolism; Staphylococcal Infections - immunology; Staphylococcal Infections - prevention & control; Staphylococcal Vaccines - immunology; Staphylococcus aureus; Staphylococcus aureus - immunology; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Th17; TIGIT; Treg; Vaccination; vaccines; host-pathogen interactions; colonization; vaccines; Treg; TIGIT; Th17; Staphylococcus aureus

Staphylococcus aureus poses an enormous burden of morbidity and mortality worldwide. Making an efficacious vaccine has however proven extremely challenging. Due to colonizing interactions, pre-existing S. aureus -specific CD4 + T cells are often found in the human population and yet a detailed chara...