Genetic–epigenetic interaction modulates µ-opioid receptor regulation

• Published in: Human molecular genetics Vol. 21; no. 21; pp. 4751 - 4760
• Main Authors: Oertel, Bruno G., Doehring, Alexandra, Roskam, Bianca, Kettner, Mattias, Hackmann, Nadja, Ferreirós, Nerea, Schmidt, Peter H., Lötsch, Jörn
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.11.2012
• Subjects: Adult; Biological and medical sciences; CpG Islands - genetics; DNA Methylation - genetics; Epigenesis, Genetic; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Genetics of eukaryotes. Biological and molecular evolution; Genotype; Heroin Dependence - genetics; Heroin Dependence - mortality; Humans; Male; Molecular and cellular biology; Polymorphism, Single Nucleotide; Receptors, Opioid, mu - genetics; Receptors, Opioid, mu - metabolism; RNA, Messenger - genetics; Signal Transduction; Epigenetics; Genetics; Regulation(control); Gene interaction; μ Opioid receptor

Genetic and epigenetic mechanisms play important roles in protein expression, although at different levels. Genetic variations can alter CpG sites and thus influence the epigenetic regulation of mRNA expression, providing an increasingly recognized mechanism of functional consequences of genetic pol...