Causal relationship between type 2 diabetes mellitus and aortic dissection: insights from two-sample Mendelian randomization and mediation analysis

• Published in: Frontiers in endocrinology (Lausanne) Vol. 15; p. 1405517
• Main Authors: Zhang, Weizong, Sun, Jindong, Yu, Huamin, Shi, Minjuan, Hu, Haiqiang, Yuan, Hong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.05.2024
• Subjects: aortic dissection; Aortic Dissection - epidemiology; Aortic Dissection - etiology; Aortic Dissection - genetics; causal relationship; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Endocrinology; FinnGen; Humans; Mediation Analysis; Mendelian randomization; Mendelian Randomization Analysis; type 2 diabetes mellitus; type 2 diabetes mellitus; mediation analysis; Mendelian randomization; causal relationship; aortic dissection; FinnGen

Some evidence suggests a reduced prevalence of type 2 diabetes mellitus (T2DM) in patients with aortic dissection (AD), a catastrophic cardiovascular illness, compared to general population. However, the conclusions were inconsistent, and the causal relationship between T2DM and AD remains unclear....