Serial determinations of HIV-1 titers in HIV-infected homosexual men: association of rising titers with CD4 T cell depletion and progression to AIDS
Lymphocyte subset enumerations, antibody titers to specific proteins of human immunodeficiency virus (HIV), and measurement of infectious HIV titers in peripheral blood mononuclear cells were performed on serial blood specimens from 15 HIV-infected homosexual men with chronic lymphadenopathy syndrom...
Saved in:
Published in | AIDS research and human retroviruses Vol. 5; no. 2; p. 205 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.04.1989
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Lymphocyte subset enumerations, antibody titers to specific proteins of human immunodeficiency virus (HIV), and measurement of infectious HIV titers in peripheral blood mononuclear cells were performed on serial blood specimens from 15 HIV-infected homosexual men with chronic lymphadenopathy syndrome (LAS); 6 of these men have subsequently progressed to AIDS (progressors), and 9 have remained clinically stable (nonprogressors). For the earliest samples studied, no test distinguished those who would progress to AIDS from those who have not. The two groups diverged significantly about 1 year before AIDS diagnosis in the progressor group. Virus titers rose in progressors but remained relatively stable in nonprogressors. CD4 T cells and the CD4 T cell subset, 4B4, declined more rapidly in progressors than in nonprogressors. HIV antibody titers tended to decline in progressors, but the differences were significant only for antibody and to the pol-encoded proteins, p51/65, and the gag-encoded polyprotein, p55. Before the onset of clinical AIDS, progressors are distinguished from nonprogressors by markedly different rates of CD4 cell depletion and virus replication, but the elements that control these dynamics remain to be defined. |
---|---|
AbstractList | Lymphocyte subset enumerations, antibody titers to specific proteins of human immunodeficiency virus (HIV), and measurement of infectious HIV titers in peripheral blood mononuclear cells were performed on serial blood specimens from 15 HIV-infected homosexual men with chronic lymphadenopathy syndrome (LAS); 6 of these men have subsequently progressed to AIDS (progressors), and 9 have remained clinically stable (nonprogressors). For the earliest samples studied, no test distinguished those who would progress to AIDS from those who have not. The two groups diverged significantly about 1 year before AIDS diagnosis in the progressor group. Virus titers rose in progressors but remained relatively stable in nonprogressors. CD4 T cells and the CD4 T cell subset, 4B4, declined more rapidly in progressors than in nonprogressors. HIV antibody titers tended to decline in progressors, but the differences were significant only for antibody and to the pol-encoded proteins, p51/65, and the gag-encoded polyprotein, p55. Before the onset of clinical AIDS, progressors are distinguished from nonprogressors by markedly different rates of CD4 cell depletion and virus replication, but the elements that control these dynamics remain to be defined. |
Author | Jones, B M Nicholson, J K Kennedy, M S Aloisio, C H Holman, R C Spira, T J McDougal, J S |
Author_xml | – sequence: 1 givenname: J K surname: Nicholson fullname: Nicholson, J K organization: Division of Host Factors, Centers for Disease Control, Atlanta, GA 30333 – sequence: 2 givenname: T J surname: Spira fullname: Spira, T J – sequence: 3 givenname: C H surname: Aloisio fullname: Aloisio, C H – sequence: 4 givenname: B M surname: Jones fullname: Jones, B M – sequence: 5 givenname: M S surname: Kennedy fullname: Kennedy, M S – sequence: 6 givenname: R C surname: Holman fullname: Holman, R C – sequence: 7 givenname: J S surname: McDougal fullname: McDougal, J S |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/2523717$$D View this record in MEDLINE/PubMed |
BookMark | eNo1kM1OAjEUhbvAIKBbdyZ9gRn7Q2em7giokJC4AN2STnsHambaSTtEfQ8f2AFxdXNuzndOcsZo4LwDhO4oSSkp5IOyJqWykKlIGREDNCJFIRPGmLxG4xg_CCGSMTFEQyYYz2k-Qj8bCFbV2EAHobFOdda7iH2Fl6v3hOLO9v-IrTtr6yrQHRh88I2P8HXsyQbcI1Yxem3P8IkNNlq3_4c_bXfA88UUb7GG-tTV1nC2KmdwG_w-QIwn3Xk8Wy02N-iqUnWE28udoLfnp-18maxfX1bz2TrRXJAukTmbqnzKNcmoKmRR5hnVGTGipJwJwk0JRikNmhrKVaUlMaTMSlWZ3q85ZRN0_5fbHssGzK4NtlHhe3dZh_0CcHponQ |
CitedBy_id | crossref_primary_10_1089_aid_1990_6_1323 crossref_primary_10_1177_230949901001800218 crossref_primary_10_1016_0022_1759_90_90221_G crossref_primary_10_1016_S0022_5193_05_80051_7 crossref_primary_10_1111_j_1464_410X_2006_06271_x crossref_primary_10_1016_S0923_2516_06_80121_4 crossref_primary_10_1016_j_ijid_2007_12_017 crossref_primary_10_1099_0022_1317_81_10_2441 crossref_primary_10_4049_jimmunol_180_1_350 crossref_primary_10_1002_ajh_2830360108 crossref_primary_10_1016_0090_1229_92_90217_C crossref_primary_10_1016_S1047_2797_96_00053_1 crossref_primary_10_1002_cyto_990220307 crossref_primary_10_1002_jmv_1890340110 crossref_primary_10_1016_0022_1759_93_90180_F crossref_primary_10_1016_j_mex_2023_102146 crossref_primary_10_1002_jmv_1890360410 crossref_primary_10_1016_0738_081X_91_90110_7 crossref_primary_10_1111_j_1600_0684_1994_tb00112_x |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1089/aid.1989.5.205 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine |
ExternalDocumentID | 2523717 |
Genre | Journal Article |
GroupedDBID | --- -~X .55 .GJ 0R~ 1-M 1CY 23M 34G 39C 4.4 53G 5GY 5RE 6J9 ABBKN ABJNI ACGFO ACGFS ACPRK ADBBV AENEX AFFNX AFRAH ALMA_UNASSIGNED_HOLDINGS BNQNF CAG CGR COF CS3 CUY CVF EBS ECM EIF EJD F5P IAO IH2 IHR IM4 INH INR ITC L7B MV1 N8Y NPM NQHIM O9- P2P RIG RML RMSOB UAP UE5 X7M ZGI |
ID | FETCH-LOGICAL-c350t-9724a743c061a898b761c60d5b132503dbedaacec1d13afc90d0b6bafd61ac312 |
ISSN | 0889-2229 |
IngestDate | Sat Sep 28 07:29:44 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c350t-9724a743c061a898b761c60d5b132503dbedaacec1d13afc90d0b6bafd61ac312 |
PMID | 2523717 |
ParticipantIDs | pubmed_primary_2523717 |
PublicationCentury | 1900 |
PublicationDate | 1989-04-01 |
PublicationDateYYYYMMDD | 1989-04-01 |
PublicationDate_xml | – month: 04 year: 1989 text: 1989-04-01 day: 01 |
PublicationDecade | 1980 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | AIDS research and human retroviruses |
PublicationTitleAlternate | AIDS Res Hum Retroviruses |
PublicationYear | 1989 |
SSID | ssj0009225 |
Score | 1.4753182 |
Snippet | Lymphocyte subset enumerations, antibody titers to specific proteins of human immunodeficiency virus (HIV), and measurement of infectious HIV titers in... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 205 |
SubjectTerms | Acquired Immunodeficiency Syndrome - immunology AIDS-Related Complex - immunology Antibodies, Monoclonal Blotting, Western HIV Antibodies - analysis HIV-1 - immunology HIV-1 - isolation & purification Homosexuality Humans Leukocyte Count Lymphocytes - microbiology Male T-Lymphocytes, Helper-Inducer |
Title | Serial determinations of HIV-1 titers in HIV-infected homosexual men: association of rising titers with CD4 T cell depletion and progression to AIDS |
URI | https://www.ncbi.nlm.nih.gov/pubmed/2523717 |
Volume | 5 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELa2RaBeKl4VlILmwC3KkrcTbtsWtK3UXtii3irHdkQldlO16YXf0d_C72PGdhJ3eQi4RJs49u56vp2MZ7_5zNjbUpQ8zbUKszQRYcaTLKwkj0LNi5rHNefKSOafnBbzs-z4PD-fTL57rKXbrp7Kb7-sK_kfq-I1tCtVyf6DZYdB8QK-RvviES2Mx7-ysU1tBaqntAystvnR5zAOjGSy4bvSuaVdYXz5pV22N0ZpOVhqQ-wQo42oN_7uTRGV7W4ytQeHWbAIKMtP3FkS7HYsZsPvstoeFMbOjg4_-fEunQdOUMjW0NlNAa91R7mM69ubkcOIoERX7CrAjr38K3EBDK7G_7BmX1sqijdp3rG-Yth4YN8leZUY-FoDC6b3elVIm4z7Ljr3kJj47taUbP_8GIhKUlEVl2pKbzHNp2s34tReLQ0oElyIc1s9-sfGNVFu17LBNnhJfvWUckS91HNitvodvkgvFVpW7-5_oi320I2ztqYxsc3iMdt2ixKYWYQ9YRO9esoenTjaxTN2Z4EG94EGbQMGaGCRApcr8IEGI9AAgfYePJhRXwuzvjPBDBBmsACCGQwwA0QNeDCDrgWC1XN29vHD4mAeuu08QpnmURdW6AgEBqwSQ0hRVmXNi1gWkcrrOMVAPFW1VkJILWMVp6KRVaSiuqhFo_B-mcbJDttcIY5eMJCpbNK4aZSIdKYTiqmVkrLA0XSV6-wl27HzeXFlNVsu3ETv_q7hFdsa0bjHHjToIvRrjDe7-o0x7w-tX4Ee |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Serial+determinations+of+HIV-1+titers+in+HIV-infected+homosexual+men%3A+association+of+rising+titers+with+CD4+T+cell+depletion+and+progression+to+AIDS&rft.jtitle=AIDS+research+and+human+retroviruses&rft.au=Nicholson%2C+J+K&rft.au=Spira%2C+T+J&rft.au=Aloisio%2C+C+H&rft.au=Jones%2C+B+M&rft.date=1989-04-01&rft.issn=0889-2229&rft.volume=5&rft.issue=2&rft.spage=205&rft_id=info:doi/10.1089%2Faid.1989.5.205&rft_id=info%3Apmid%2F2523717&rft_id=info%3Apmid%2F2523717&rft.externalDocID=2523717 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0889-2229&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0889-2229&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0889-2229&client=summon |