Focal segmental glomerulosclerosis associated with polycythemia vera: report of a case and review of the literature

A 69-year-old female with a 3-year history of polycythemia vera (PV) developed nephrotic syndrome. A renal biopsy showed focal and segmental glomerulosclerosis (FSGS). The patient was treated with prednisolone and myelosuppressive agents. Thereafter, parallel improvement of the two conditions was ob...

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Published inClinical nephrology Vol. 68; no. 6; p. 412
Main Authors Okuyama, S, Hamai, K, Fujishima, M, Ohtani, H, Komatsuda, A, Sawada, K, Wakui, H
Format Journal Article
LanguageEnglish
Published Germany 01.12.2007
Subjects
Aged
Female
Glomerulosclerosis, Focal Segmental - complications
Glomerulosclerosis, Focal Segmental - pathology
Humans
Polycythemia Vera - complications
Polycythemia Vera - pathology
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Abstract A 69-year-old female with a 3-year history of polycythemia vera (PV) developed nephrotic syndrome. A renal biopsy showed focal and segmental glomerulosclerosis (FSGS). The patient was treated with prednisolone and myelosuppressive agents. Thereafter, parallel improvement of the two conditions was observed. After 4-year treatment, proteinuria disappeared. To our knowledge, there are five reported cases of FSGS associated with PV. Among them, three patients suffered from progressive azotemia. We suggest that steroid therapy with myelosuppressive agents can resolve the renal lesion in patients with PV.
AbstractList A 69-year-old female with a 3-year history of polycythemia vera (PV) developed nephrotic syndrome. A renal biopsy showed focal and segmental glomerulosclerosis (FSGS). The patient was treated with prednisolone and myelosuppressive agents. Thereafter, parallel improvement of the two conditions was observed. After 4-year treatment, proteinuria disappeared. To our knowledge, there are five reported cases of FSGS associated with PV. Among them, three patients suffered from progressive azotemia. We suggest that steroid therapy with myelosuppressive agents can resolve the renal lesion in patients with PV.
Author Komatsuda, A
Hamai, K
Fujishima, M
Wakui, H
Okuyama, S
Sawada, K
Ohtani, H
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Snippet A 69-year-old female with a 3-year history of polycythemia vera (PV) developed nephrotic syndrome. A renal biopsy showed focal and segmental glomerulosclerosis...
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SubjectTerms Aged
Female
Glomerulosclerosis, Focal Segmental - complications
Glomerulosclerosis, Focal Segmental - pathology
Humans
Polycythemia Vera - complications
Polycythemia Vera - pathology
Title Focal segmental glomerulosclerosis associated with polycythemia vera: report of a case and review of the literature
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Volume 68
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