Photochemical α-selective radical ring-opening reactions of 1,3-disubstituted acyl bicyclobutanes with alkyl halides: modular access to functionalized cyclobutenes

• Published in: Chemical science (Cambridge) Vol. 14; no. 45; pp. 136 - 1366
• Main Authors: Xiao, Yuanjiu, Xu, Tong-Tong, Zhou, Jin-Lan, Wu, Feng, Tang, Lei, Liu, Ruo-Yi, Wu, Wen-Biao, Feng, Jian-Jun
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 22.11.2023; Royal Society of Chemistry
• Subjects: Chemistry; Chemistry, Multidisciplinary; Halides; Photochemical reactions; Physical Sciences; Ring opening; Science & Technology; Substrates; Synthesis; INTERMOLECULAR 2+2 CYCLOADDITION; MERGING PHOTOREDOX; STRAIN-RELEASE; ENANTIOSELECTIVE SYNTHESIS; BUILDING-BLOCKS; CHEMISTRY; GENERATION; ADDITIONS; DERIVATIVES; PHOTOREDOX CATALYSIS

Although ring-opening reactions of bicyclobutanes bearing electron-withdrawing groups, typically with β-selectivity, have evolved as a powerful platform for synthesis of cyclobutanes, their application in the synthesis of cyclobutenes remains underdeveloped. Here, a novel visible light induced α-sel...