Development and application of a fully automatic multi-function cassette module Mortenon M1 for radiopharmaceutical synthesis

• Published in: Annals of nuclear medicine Vol. 38; no. 4; pp. 247 - 263
• Main Authors: Cui, Fang-Bo, Lv, Xuan, Yan, Cheng-Long, Eng, Wai-Si, Yu, Shan-You, Zheng, Qi-Huang
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.04.2024; Springer Nature B.V
• Subjects: Animal models; Animals; Antibodies; Cassettes; Chemical synthesis; Control methods; Diagnosis; Drugs; Functional testing; Gallium isotopes; Gallium Radioisotopes - chemistry; Humans; Imaging; Macromolecules; Medicine; Medicine & Public Health; Mice; Modules; Neoplasms; Nuclear Medicine; Nuclides; Original Article; Peptides; Pharmaceuticals; Production methods; Purity; Quality control; Radiation effects; Radioactive tracers; Radiochemistry; Radioisotopes; Radioisotopes - chemistry; Radiolabelling; Radiology; Radiopharmaceuticals - chemistry; Substrates; Tumors; Xenografts; Xenotransplantation; Zirconium isotopes; Automatic module; Ga]-FAPI-46; Zr]-TROP2 antibody; [; Radiopharmaceuticals; Labeling synthesis; [89Zr]-TROP2 antibody; [68Ga]-FAPI-46

Introduction Functions of existing automatic module systems for synthesis of radiopharmaceuticals mainly focus on the radiolabeling of small molecules. There are few modules which have achieved full-automatic radiolabeling of non-metallic and metallic nuclides on small molecules, peptides, and antib...