Infralimbic prefrontal cortex interacts with nucleus accumbens shell to unmask expression of outcome-selective Pavlovian-to-instrumental transfer
Although several studies have examined the subcortical circuitry underlying Pavlovian-to-instrumental transfer (PIT), the role of medial prefrontal cortex in this behavior is largely unknown. Elucidating the cortical contributions to PIT will be key for understanding how reward-paired cues control b...
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| Published in | Learning & memory (Cold Spring Harbor, N.Y.) Vol. 22; no. 10; pp. 509 - 513 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Cold Spring Harbor Laboratory Press
01.10.2015
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| Abstract | Although several studies have examined the subcortical circuitry underlying Pavlovian-to-instrumental transfer (PIT), the role of medial prefrontal cortex in this behavior is largely unknown. Elucidating the cortical contributions to PIT will be key for understanding how reward-paired cues control behavior in both adaptive and maladaptive context (i.e., addiction). Here we use bilateral lesions in a rat model to show that infralimbic prefrontal cortex (ilPFC) is necessary for appropriate expression of PIT. Further, we show that ilPFC mediates this effect via functional connectivity with nucleus accumbens shell (NAcS). Together, these data provide the first demonstration that a specific cortico-striatal circuit is necessary for cue-invigorated reward seeking during specific PIT. |
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| AbstractList | Although several studies have examined the subcortical circuitry underlying Pavlovian-to-instrumental transfer (PIT), the role of medial prefrontal cortex in this behavior is largely unknown. Elucidating the cortical contributions to PIT will be key for understanding how reward-paired cues control behavior in both adaptive and maladaptive context (i.e., addiction). Here we use bilateral lesions in a rat model to show that infralimbic prefrontal cortex (ilPFC) is necessary for appropriate expression of PIT. Further, we show that ilPFC mediates this effect via functional connectivity with nucleus accumbens shell (NAcS). Together, these data provide the first demonstration that a specific cortico-striatal circuit is necessary for cue-invigorated reward seeking during specific PIT. |
| Author | Taylor, Jane R Keistler, Colby Barker, Jacqueline M |
| AuthorAffiliation | 3 Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA 2 Department of Psychology, Yale University, New Haven, Connecticut 06520, USA 1 Department of Psychiatry, Division of Molecular Psychiatry, New Haven, Connecticut 06520, USA |
| AuthorAffiliation_xml | – name: 3 Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA – name: 2 Department of Psychology, Yale University, New Haven, Connecticut 06520, USA – name: 1 Department of Psychiatry, Division of Molecular Psychiatry, New Haven, Connecticut 06520, USA |
| Author_xml | – sequence: 1 givenname: Colby surname: Keistler fullname: Keistler, Colby organization: Department of Psychiatry, Division of Molecular Psychiatry, New Haven, Connecticut 06520, USA Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA – sequence: 2 givenname: Jacqueline M surname: Barker fullname: Barker, Jacqueline M organization: Department of Psychiatry, Division of Molecular Psychiatry, New Haven, Connecticut 06520, USA – sequence: 3 givenname: Jane R surname: Taylor fullname: Taylor, Jane R email: jane.taylor@yale.edu organization: Department of Psychiatry, Division of Molecular Psychiatry, New Haven, Connecticut 06520, USA Department of Psychology, Yale University, New Haven, Connecticut 06520, USA Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA jane.taylor@yale.edu |
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| SubjectTerms | Animals Brief Communication Conditioning, Classical - physiology Conditioning, Operant - physiology Extinction, Psychological - physiology Male Neural Pathways - physiology Nucleus Accumbens - physiology Prefrontal Cortex - physiology Rats Rats, Sprague-Dawley Transfer (Psychology) - physiology |
| Title | Infralimbic prefrontal cortex interacts with nucleus accumbens shell to unmask expression of outcome-selective Pavlovian-to-instrumental transfer |
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