Cellular tolerance to pulsed hyperthermia

• Published in: Physical review. E, Statistical, nonlinear, and soft matter physics Vol. 74; no. 1 Pt 1; p. 011915
• Main Authors: Simanovskii, D M, Mackanos, M A, Irani, A R, O'Connell-Rodwell, C E, Contag, C H, Schwettman, H A, Palanker, D V
• Format: Journal Article
• Language: English
• Published: United States 01.07.2006
• Subjects: Animals; Apoptosis - radiation effects; Cell Survival - radiation effects; Computer Simulation; Dose-Response Relationship, Radiation; Fever - pathology; Fever - physiopathology; Hot Temperature; Lasers; Linear Energy Transfer - physiology; Mice; Models, Biological; NIH 3T3 Cells; Radiation Dosage

Transient heating of tissues leading to cellular stress or death is very common in medicine and biology. In procedures involving a mild (below 70 degrees C) and prolonged (minutes) heating, such as hyperthermal tumor therapy, the cellular response to thermal stress is relatively well studied. Howeve...