CYP2C19 Plays a Major Role in the Hepatic N -Oxidation of Cotinine

• Published in: Drug metabolism and disposition Vol. 51; no. 1; pp. 29 - 37
• Main Authors: Perez-Paramo, Yadira X, Watson, Christy J W, Chen, Gang, Lazarus, Philip
• Format: Journal Article
• Language: English
• Published: United States The American Society for Pharmacology and Experimental Therapeutics 01.01.2023
• Subjects: Cotinine - metabolism; Cytochrome P-450 CYP2B6 - metabolism; Cytochrome P-450 CYP2C19 - genetics; Cytochrome P-450 CYP2C19 - metabolism; Cytochrome P-450 CYP2E1 - metabolism; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 Enzyme System - metabolism; HEK293 Cells; Humans; Kinetics; Liver - metabolism; Microsomes, Liver - metabolism; Nicotine - metabolism

The primary mode of metabolism of nicotine is via the formation of cotinine by the enzyme CYP2A6. Cotinine undergoes further CYP2A6-mediated metabolism by hydroxylation to 3-hydroxycotinine and norcotinine, but can also form cotinine- -glucuronide and cotinine- -oxide (COX). The goal of this study w...