UBQLN1 links proteostasis and mitochondria function to telomere maintenance in human embryonic stem cells

• Published in: Stem cell research & therapy Vol. 15; no. 1; pp. 180 - 19
• Main Authors: Zhao, Shuang, Li, Jie, Duan, Songqi, Liu, Chang, Wang, Hua, Lu, Jiangtao, Zhao, Nannan, Sheng, Xiaoyan, Wu, Yiwei, Li, Yanjun, Sun, Baofa, Liu, Lin
• Format: Journal Article
• Language: English
• Published: England BioMed Central 21.06.2024; BMC
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Autophagy-Related Proteins - genetics; Autophagy-Related Proteins - metabolism; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; DNA Damage; hESC differentiation; Human Embryonic Stem Cells - cytology; Human Embryonic Stem Cells - metabolism; Humans; Mitochondria; Mitochondria - metabolism; Oxidative Stress; Proteostasis; Telomere; Telomere - metabolism; Telomere Homeostasis; Ubiquitin-proteasome; UBQLN1; UBQLN1; Mitochondria; Proteostasis; Telomere; hESC differentiation; Ubiquitin-proteasome

Telomeres consist of repetitive DNA sequences at the chromosome ends to protect chromosomal stability, and primarily maintained by telomerase or occasionally by alternative telomere lengthening of telomeres (ALT) through recombination-based mechanisms. Additional mechanisms that may regulate telomer...