Shared intrinsic functional connectivity alterations as a familial risk marker for ADHD: a resting-state functional magnetic resonance imaging study with sibling design

• Published in: Psychological medicine Vol. 52; no. 9; pp. 1736 - 1745
• Main Authors: Chiang, Huey-Ling, Tseng, Wen-Yih Isaac, Wey, Hsiao-Ying, Gau, Susan Shur-Fen
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.07.2022
• Subjects: Adults; Age; Attention deficit hyperactivity disorder; Brain; Brain mapping; Brain research; Child & adolescent psychiatry; Cortex; Cortex (cingulate); Cortex (parietal); Familial factors; Frontal gyrus; Functional connectivity; Functional magnetic resonance imaging; Hyperactivity; Magnetic resonance imaging; Mental disorders; Neural networks; Neuroimaging; Neuropsychology; Original Article; Response inhibition; Resting; Severity; Siblings; Temporal cortex; Taiwan; resting-state functional magnetic resonance imaging; intrinsic functional connectivity; unaffected siblings; Attention-deficit/hyperactivity disorder; familial risk

BackgroundAlthough aberrant intrinsic functional connectivity has been reported in attention-deficit/hyperactivity disorder (ADHD), we have a limited understanding of whether connectivity alterations are related to the familial risk of ADHD.MethodsFifty-three probands with ADHD, their unaffected sib...