Use of whole genomic sequencing to detect New Delhi metallo-B-lactamase (NDM)-producing Escherichia coli outbreak associated with endoscopic procedures

• Published in: Infection control and hospital epidemiology Vol. 45; no. 8; pp. 965 - 972
• Main Authors: Suleyman, Geehan, Shallal, Anita, Ruby, Abigail, Chami, Eman, Gubler, Jenny, McNamara, Sara, Miles-Jay, Arianna, Tibbetts, Robert, Alangaden, George
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01.08.2024
• Subjects: Adult; Aged; Aged, 80 and over; Antimicrobial agents; Bacterial infections; beta-Lactamases - genetics; Bile; Case-Control Studies; Cholangitis; Cross Infection - epidemiology; Cross Infection - microbiology; Disease control; Disease Outbreaks; Disease transmission; E coli; Endoscopy; Endoscopy - adverse effects; Epidemics; Epidemiology; Escherichia coli - genetics; Escherichia coli - isolation & purification; Escherichia coli Infections - epidemiology; Escherichia coli Infections - microbiology; Escherichia coli Infections - transmission; Female; Females; Genomes; Hospitalization; Humans; Infection Control - methods; Laboratories; Liver transplants; Male; Medical research; Metastasis; Michigan - epidemiology; Middle Aged; Original Article; Outbreaks; Patients; Phylogeny; Polymorphism, Single Nucleotide; Public health; Whole Genome Sequencing; Michigan; United States > US

Whole-genome sequencing (WGS) has emerged as an alternative genotyping tool for outbreak investigations in the healthcare setting. We describe the investigation and control of a New Delhi metallo-B-lactamase (NDM)-producing cluster in Southeast Michigan. Michigan Bureau of Laboratories identified se...