Hazardous impacts of silver nanoparticles on mouse oocyte maturation and fertilization and fetal development through induction of apoptotic processes
Silver nanoparticles (AgNPs) are antibacterial materials widely used in numerous products and medical supplies. Previously, we showed that AgNPs trigger apoptotic processes in mouse blastocysts, leading to a decrease in cell viability and impairment of preimplantation and postimplantation embryonic...
Saved in:
| Published in | Environmental toxicology Vol. 33; no. 10; pp. 1039 - 1049 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wiley Subscription Services, Inc
01.10.2018
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Silver nanoparticles (AgNPs) are antibacterial materials widely used in numerous products and medical supplies. Previously, we showed that AgNPs trigger apoptotic processes in mouse blastocysts, leading to a decrease in cell viability and impairment of preimplantation and postimplantation embryonic development in vitro and in vivo. In the present study, we further investigated the hazardous effects of AgNPs on mouse oocyte maturation, in vitro fertilization (IVF), and subsequent preimplantation and postimplantation development in vitro and in vivo. Data from in vitro experiments revealed that AgNPs impair mouse oocyte maturation, decrease IVF rates, and induce injury effects on subsequent embryonic development to a significant extent. In an animal model, intravenous injection of AgNPs (5 mg/kg body weight) led to a significant decrease in mouse oocyte maturation and IVF concomitant with impairment of early embryonic development in vivo. Importantly, pretreatment with N-acetylcysteine effectively prevented AgNP-triggered reactive oxygen species (ROS) production and apoptosis, clearly suggesting a critical role of ROS as an upstream initiator or key regulator of AgNP-induced hazardous effects on oocyte maturation and sequent embryonic development. Furthermore, preincubation of oocytes with Ac-DEVD-cho, a caspase-3-specific inhibitor, effectively prevented hazardous effects, highlighting the potential involvement of caspase-dependent apoptotic signaling cascades in AgNP-mediated events. Expression levels of p53 and p21 of blastocysts were upregulated upon preincubation of mouse oocytes with AgNPs. Our collective results imply that cell apoptosis in mouse blastocysts derived from the AgNP-pretreated oocytes via intracellular ROS generation, which is further mediated through p53-, p21-, and caspase-3-dependent regulatory mechanisms. |
|---|---|
| AbstractList | Abstract
Silver nanoparticles (AgNPs) are antibacterial materials widely used in numerous products and medical supplies. Previously, we showed that AgNPs trigger apoptotic processes in mouse blastocysts, leading to a decrease in cell viability and impairment of preimplantation and postimplantation embryonic development in vitro and in vivo. In the present study, we further investigated the hazardous effects of AgNPs on mouse oocyte maturation, in vitro fertilization (IVF), and subsequent preimplantation and postimplantation development in vitro and in vivo. Data from in vitro experiments revealed that AgNPs impair mouse oocyte maturation, decrease IVF rates, and induce injury effects on subsequent embryonic development to a significant extent. In an animal model, intravenous injection of AgNPs (5 mg/kg body weight) led to a significant decrease in mouse oocyte maturation and IVF concomitant with impairment of early embryonic development in vivo. Importantly, pretreatment with
N‐
acetylcysteine effectively prevented AgNP‐triggered reactive oxygen species (ROS) production and apoptosis, clearly suggesting a critical role of ROS as an upstream initiator or key regulator of AgNP‐induced hazardous effects on oocyte maturation and sequent embryonic development. Furthermore, preincubation of oocytes with Ac‐DEVD‐cho, a caspase‐3‐specific inhibitor, effectively prevented hazardous effects, highlighting the potential involvement of caspase‐dependent apoptotic signaling cascades in AgNP‐mediated events. Expression levels of p53 and p21 of blastocysts were upregulated upon preincubation of mouse oocytes with AgNPs. Our collective results imply that cell apoptosis in mouse blastocysts derived from the AgNP‐pretreated oocytes via intracellular ROS generation, which is further mediated through p53‐, p21‐, and caspase‐3‐dependent regulatory mechanisms. Silver nanoparticles (AgNPs) are antibacterial materials widely used in numerous products and medical supplies. Previously, we showed that AgNPs trigger apoptotic processes in mouse blastocysts, leading to a decrease in cell viability and impairment of preimplantation and postimplantation embryonic development in vitro and in vivo. In the present study, we further investigated the hazardous effects of AgNPs on mouse oocyte maturation, in vitro fertilization (IVF), and subsequent preimplantation and postimplantation development in vitro and in vivo. Data from in vitro experiments revealed that AgNPs impair mouse oocyte maturation, decrease IVF rates, and induce injury effects on subsequent embryonic development to a significant extent. In an animal model, intravenous injection of AgNPs (5 mg/kg body weight) led to a significant decrease in mouse oocyte maturation and IVF concomitant with impairment of early embryonic development in vivo. Importantly, pretreatment with N‐acetylcysteine effectively prevented AgNP‐triggered reactive oxygen species (ROS) production and apoptosis, clearly suggesting a critical role of ROS as an upstream initiator or key regulator of AgNP‐induced hazardous effects on oocyte maturation and sequent embryonic development. Furthermore, preincubation of oocytes with Ac‐DEVD‐cho, a caspase‐3‐specific inhibitor, effectively prevented hazardous effects, highlighting the potential involvement of caspase‐dependent apoptotic signaling cascades in AgNP‐mediated events. Expression levels of p53 and p21 of blastocysts were upregulated upon preincubation of mouse oocytes with AgNPs. Our collective results imply that cell apoptosis in mouse blastocysts derived from the AgNP‐pretreated oocytes via intracellular ROS generation, which is further mediated through p53‐, p21‐, and caspase‐3‐dependent regulatory mechanisms. |
| Author | Chan, Wen-Hsiung Yeh, Jui-Ming Huang, Chien-Hsun |
| Author_xml | – sequence: 1 givenname: Chien-Hsun surname: Huang fullname: Huang, Chien-Hsun organization: Department of Obstetrics and Gynecology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City, Taiwan – sequence: 2 givenname: Jui-Ming surname: Yeh fullname: Yeh, Jui-Ming organization: Department of Chemistry and Center for Nanotechnology, Chung Yuan Christian University, Taoyuan City, Taiwan – sequence: 3 givenname: Wen-Hsiung orcidid: 0000-0002-9999-0731 surname: Chan fullname: Chan, Wen-Hsiung organization: Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29964317$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkc1KAzEUhYNU7I8ufAEJuHIxNcn8ZilFrVBwo-shk7mxU2aSMckU2_fwfY2tiqt7OXzcwz1nikbaaEDokpI5JYTdevMxZyzl5ARNaMpYlLO8GB12EiWkoGM0dW5DCOFZmp2hMeM8S2KaT9DnUuyFrc3gcNP1QnqHjcKuabdgsRba9ML6RrYQdI27wAE2Ru484E74wQrfBF3oGisIYNvs_ytetLiGLbSm70B77NfWDG9r3Oh6kAcumIne9N4EE9xbI8E5cOfoVInWwcXPnKHXh_uXxTJaPT8-Le5WkYxT4qMEAISsOMvCw8AgJBDnFQNSC1HxTLEkjpnKkixNVZ7LIs5EUeUJ5TLhSlYqnqHr493g_D6A8-XGDFYHy5JRQnnIiaSBujlS0hrnLKiyt00n7K6kpPwuoAwFlIcCAnv1c3GoOqj_yN_E4y-NS4do |
| CitedBy_id | crossref_primary_10_3390_biom10050777 crossref_primary_10_3390_ijms23168839 crossref_primary_10_1016_j_fct_2021_112053 crossref_primary_10_3390_antiox10030393 crossref_primary_10_1038_s41598_023_36441_5 crossref_primary_10_3390_antiox11030587 crossref_primary_10_1002_tox_22771 crossref_primary_10_1016_j_bej_2021_107937 crossref_primary_10_3390_cancers13102450 crossref_primary_10_3390_ph15080917 crossref_primary_10_1016_j_matdes_2021_109611 crossref_primary_10_1038_s41598_024_65121_1 crossref_primary_10_1155_2021_6667355 crossref_primary_10_3390_antiox11091777 crossref_primary_10_3390_cells11040641 crossref_primary_10_1038_s41598_022_23276_9 crossref_primary_10_3390_antiox11091797 crossref_primary_10_3390_antiox10101588 crossref_primary_10_1093_toxres_tfac028 crossref_primary_10_3390_ani11092483 crossref_primary_10_3390_ijms24097751 crossref_primary_10_3390_antiox9080694 crossref_primary_10_3390_biomedicines12020458 crossref_primary_10_3390_ijms24108853 crossref_primary_10_1002_tox_24002 crossref_primary_10_1007_s00204_024_03699_1 crossref_primary_10_1016_j_meegid_2021_104937 crossref_primary_10_3390_antiox11102072 crossref_primary_10_3390_antiox11050841 crossref_primary_10_1002_tox_22986 crossref_primary_10_3390_antiox11101982 crossref_primary_10_3390_antiox11050926 crossref_primary_10_3390_biomedicines10051196 crossref_primary_10_1002_tox_22748 crossref_primary_10_3390_ijms23062981 crossref_primary_10_3390_ijms24043987 crossref_primary_10_1016_j_envint_2020_105627 crossref_primary_10_3390_ph17020230 crossref_primary_10_3390_antiox9090873 crossref_primary_10_3390_cancers11091303 crossref_primary_10_3390_ijms20133238 crossref_primary_10_3390_jpm11090871 crossref_primary_10_1002_mrd_23536 crossref_primary_10_3390_antiox11071352 crossref_primary_10_3390_antiox11112227 crossref_primary_10_3390_antiox9090876 |
| Cites_doi | 10.1128/AEM.69.7.4278-4281.2003 10.3168/jds.S0022-0302(02)74367-1 10.1093/humrep/dem203 10.1016/j.biomaterials.2010.07.045 10.1002/iub.30 10.1126/science.7985020 10.1530/jrf.0.1170097 10.1093/toxsci/kfh041 10.1016/j.chemosphere.2016.12.016 10.3762/bjnano.6.181 10.2337/diab.39.4.471 10.1089/sur.2006.032 10.1021/nn800596w 10.1038/nrc1412 10.3390/ijms13044655 10.1016/0147-619X(92)90008-X 10.1007/s10495-007-0756-2 10.1016/j.toxlet.2011.06.018 10.1021/es7032718 10.1166/jnn.2007.737 10.1016/j.taap.2009.10.016 10.1016/j.tox.2012.05.006 10.1186/1743-8977-2-8 10.1242/dev.107.3.597 10.1042/BJ20061875 10.3390/ijms131113911 10.1002/jcp.20408 10.1002/tox.22085 10.1293/tox.2017-0043 10.1080/152165400410281 10.3390/ijms141020139 10.1016/j.cca.2010.08.016 10.1002/tox.22416 10.1021/es801785m 10.1016/j.reprotox.2009.03.014 10.3390/ijms14010935 10.1038/srep11170 10.1021/jp712087m 10.3390/ijms10041445 10.1088/0957-4484/19/23/235104 10.1002/jcp.10119 10.1093/humrep/del255 10.1016/j.toxlet.2009.07.009 10.1002/jbm.a.30819 10.1016/j.biomaterials.2007.12.037 10.1016/j.toxlet.2010.05.003 10.1002/tox.22366 10.1016/j.taap.2008.09.015 10.1016/j.biotechadv.2008.09.002 10.1002/jez.1402650108 10.1016/j.toxlet.2008.05.011 10.1016/j.tox.2007.09.015 10.1166/jnn.2008.1193 10.1166/jnn.2014.9526 10.1002/tox.21969 10.1021/ja058083c 10.1016/B978-0-444-53864-2.00005-0 10.1158/0008-5472.CAN-03-1880 10.1016/j.freeradbiomed.2007.06.014 10.1021/ja061442z 10.1186/1471-2121-10-65 10.1016/j.theriogenology.2007.06.005 10.1016/j.toxlet.2009.03.004 |
| ContentType | Journal Article |
| Copyright | 2018 Wiley Periodicals, Inc. |
| Copyright_xml | – notice: 2018 Wiley Periodicals, Inc. |
| DBID | NPM AAYXX CITATION 7QH 7ST 7TN 7U7 7UA C1K F1W H97 K9. L.G M7N SOI |
| DOI | 10.1002/tox.22590 |
| DatabaseName | PubMed CrossRef Aqualine Environment Abstracts Oceanic Abstracts Toxicology Abstracts Water Resources Abstracts Environmental Sciences and Pollution Management ASFA: Aquatic Sciences and Fisheries Abstracts Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality ProQuest Health & Medical Complete (Alumni) Aquatic Science & Fisheries Abstracts (ASFA) Professional Algology Mycology and Protozoology Abstracts (Microbiology C) Environment Abstracts |
| DatabaseTitle | PubMed CrossRef Aquatic Science & Fisheries Abstracts (ASFA) Professional Oceanic Abstracts Toxicology Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) ASFA: Aquatic Sciences and Fisheries Abstracts ProQuest Health & Medical Complete (Alumni) Aqualine Environment Abstracts Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality Water Resources Abstracts Environmental Sciences and Pollution Management |
| DatabaseTitleList | CrossRef Aquatic Science & Fisheries Abstracts (ASFA) Professional PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Ecology Oceanography |
| EISSN | 1522-7278 |
| EndPage | 1049 |
| ExternalDocumentID | 10_1002_tox_22590 29964317 |
| Genre | Journal Article |
| GroupedDBID | --- .3N .GA 05W 0R~ 10A 1L6 1OC 33P 3SF 3WU 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5GY 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABPVW ACAHQ ACCFJ ACCZN ACGFS ACPOU ACPRK ACSCC ACXBN ACXME ACXQS ADBBV ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHMBA AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ATUGU AUFTA AZBYB AZVAB BAFTC BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BY8 CS3 D-E D-F DCZOG DPXWK DR2 DRFUL DRSTM DU5 EBD EBS EJD EMOBN F00 F01 F04 F5P G-S G.N GNP GODZA H.T H.X HGLYW HZ~ IX1 J0M JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ NNB NPM O66 O9- OIG P2P P2W P2X P4D PQQKQ Q.N Q11 QB0 QRW R.K ROL RWI RX1 RYL SUPJJ SV3 UB1 V2E W8V W99 WBKPD WIH WIK WOHZO WQJ WRC WUPDE WXSBR WYISQ XG1 XPP XV2 ~IA ~KM ~WT .Y3 31~ AAHBH AAYXX ACBWZ AI. AITYG ASPBG AVWKF AZFZN BDRZF CITATION FEDTE HF~ HVGLF VH1 7QH 7ST 7TN 7U7 7UA C1K F1W H97 K9. L.G M7N SOI |
| ID | FETCH-LOGICAL-c350t-4eeeacb926727e2e59037b2e0daab96f24332f64655f77c836a8b7419c49fcbf3 |
| ISSN | 1520-4081 |
| IngestDate | Fri Sep 13 05:20:41 EDT 2024 Fri Aug 23 01:04:14 EDT 2024 Fri May 24 00:05:44 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | apoptosis oocyte maturation silver nanoparticles embryonic development |
| Language | English |
| License | 2018 Wiley Periodicals, Inc. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c350t-4eeeacb926727e2e59037b2e0daab96f24332f64655f77c836a8b7419c49fcbf3 |
| ORCID | 0000-0002-9999-0731 |
| PMID | 29964317 |
| PQID | 2101929905 |
| PQPubID | 866374 |
| PageCount | 11 |
| ParticipantIDs | proquest_journals_2101929905 crossref_primary_10_1002_tox_22590 pubmed_primary_29964317 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-10-01 |
| PublicationDateYYYYMMDD | 2018-10-01 |
| PublicationDate_xml | – month: 10 year: 2018 text: 2018-10-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Environmental toxicology |
| PublicationTitleAlternate | Environ Toxicol |
| PublicationYear | 2018 |
| Publisher | Wiley Subscription Services, Inc |
| Publisher_xml | – name: Wiley Subscription Services, Inc |
| References | e_1_2_7_5_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_60_1 e_1_2_7_17_1 e_1_2_7_62_1 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_64_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_66_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_47_1 e_1_2_7_26_1 e_1_2_7_49_1 e_1_2_7_28_1 Zhang XF (e_1_2_7_40_1) 2015; 10 e_1_2_7_50_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_52_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_54_1 Devasagayam TPT (e_1_2_7_57_1) 2004; 52 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_56_1 e_1_2_7_37_1 e_1_2_7_58_1 e_1_2_7_39_1 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_8_1 e_1_2_7_18_1 e_1_2_7_16_1 e_1_2_7_61_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_63_1 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_65_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_48_1 e_1_2_7_27_1 e_1_2_7_29_1 e_1_2_7_51_1 e_1_2_7_30_1 e_1_2_7_53_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_55_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_20_1 e_1_2_7_36_1 e_1_2_7_59_1 e_1_2_7_38_1 |
| References_xml | – ident: e_1_2_7_13_1 doi: 10.1128/AEM.69.7.4278-4281.2003 – ident: e_1_2_7_30_1 doi: 10.3168/jds.S0022-0302(02)74367-1 – ident: e_1_2_7_31_1 doi: 10.1093/humrep/dem203 – ident: e_1_2_7_50_1 doi: 10.1016/j.biomaterials.2010.07.045 – ident: e_1_2_7_48_1 doi: 10.1002/iub.30 – ident: e_1_2_7_56_1 doi: 10.1126/science.7985020 – ident: e_1_2_7_36_1 doi: 10.1530/jrf.0.1170097 – ident: e_1_2_7_3_1 doi: 10.1093/toxsci/kfh041 – ident: e_1_2_7_29_1 doi: 10.1016/j.chemosphere.2016.12.016 – ident: e_1_2_7_7_1 doi: 10.3762/bjnano.6.181 – ident: e_1_2_7_44_1 doi: 10.2337/diab.39.4.471 – ident: e_1_2_7_4_1 doi: 10.1089/sur.2006.032 – ident: e_1_2_7_51_1 doi: 10.1021/nn800596w – ident: e_1_2_7_63_1 doi: 10.1038/nrc1412 – ident: e_1_2_7_33_1 doi: 10.3390/ijms13044655 – ident: e_1_2_7_16_1 doi: 10.1016/0147-619X(92)90008-X – ident: e_1_2_7_17_1 doi: 10.1007/s10495-007-0756-2 – ident: e_1_2_7_25_1 doi: 10.1016/j.toxlet.2011.06.018 – ident: e_1_2_7_9_1 doi: 10.1021/es7032718 – ident: e_1_2_7_10_1 doi: 10.1166/jnn.2007.737 – ident: e_1_2_7_20_1 doi: 10.1016/j.taap.2009.10.016 – ident: e_1_2_7_24_1 doi: 10.1016/j.tox.2012.05.006 – ident: e_1_2_7_2_1 doi: 10.1186/1743-8977-2-8 – ident: e_1_2_7_46_1 doi: 10.1242/dev.107.3.597 – ident: e_1_2_7_19_1 doi: 10.1042/BJ20061875 – ident: e_1_2_7_34_1 doi: 10.3390/ijms131113911 – ident: e_1_2_7_37_1 doi: 10.1002/jcp.20408 – ident: e_1_2_7_65_1 doi: 10.1002/tox.22085 – ident: e_1_2_7_42_1 doi: 10.1293/tox.2017-0043 – ident: e_1_2_7_60_1 doi: 10.1080/152165400410281 – ident: e_1_2_7_66_1 doi: 10.3390/ijms141020139 – ident: e_1_2_7_12_1 doi: 10.1016/j.cca.2010.08.016 – ident: e_1_2_7_28_1 doi: 10.1002/tox.22416 – ident: e_1_2_7_14_1 doi: 10.1021/es801785m – ident: e_1_2_7_39_1 doi: 10.1016/j.reprotox.2009.03.014 – ident: e_1_2_7_23_1 doi: 10.3390/ijms14010935 – ident: e_1_2_7_41_1 doi: 10.1038/srep11170 – ident: e_1_2_7_61_1 doi: 10.1021/jp712087m – ident: e_1_2_7_64_1 doi: 10.3390/ijms10041445 – volume: 10 start-page: 7057 year: 2015 ident: e_1_2_7_40_1 article-title: Silver nanoparticles cause complications in pregnant mice publication-title: Int J Nanomedicine contributor: fullname: Zhang XF – ident: e_1_2_7_54_1 doi: 10.1088/0957-4484/19/23/235104 – ident: e_1_2_7_59_1 doi: 10.1002/jcp.10119 – ident: e_1_2_7_18_1 doi: 10.1093/humrep/del255 – ident: e_1_2_7_21_1 doi: 10.1016/j.toxlet.2009.07.009 – ident: e_1_2_7_5_1 doi: 10.1002/jbm.a.30819 – ident: e_1_2_7_49_1 doi: 10.1016/j.biomaterials.2007.12.037 – ident: e_1_2_7_22_1 doi: 10.1016/j.toxlet.2010.05.003 – ident: e_1_2_7_27_1 doi: 10.1002/tox.22366 – ident: e_1_2_7_52_1 doi: 10.1016/j.taap.2008.09.015 – ident: e_1_2_7_8_1 doi: 10.1016/j.biotechadv.2008.09.002 – ident: e_1_2_7_47_1 doi: 10.1002/jez.1402650108 – ident: e_1_2_7_35_1 doi: 10.1016/j.toxlet.2008.05.011 – ident: e_1_2_7_45_1 doi: 10.1016/j.tox.2007.09.015 – ident: e_1_2_7_6_1 doi: 10.1166/jnn.2008.1193 – ident: e_1_2_7_11_1 doi: 10.1166/jnn.2014.9526 – ident: e_1_2_7_26_1 doi: 10.1002/tox.21969 – ident: e_1_2_7_43_1 doi: 10.1021/ja058083c – ident: e_1_2_7_55_1 doi: 10.1016/B978-0-444-53864-2.00005-0 – ident: e_1_2_7_62_1 doi: 10.1158/0008-5472.CAN-03-1880 – ident: e_1_2_7_58_1 doi: 10.1016/j.freeradbiomed.2007.06.014 – ident: e_1_2_7_15_1 doi: 10.1021/ja061442z – ident: e_1_2_7_53_1 doi: 10.1186/1471-2121-10-65 – ident: e_1_2_7_32_1 doi: 10.1016/j.theriogenology.2007.06.005 – ident: e_1_2_7_38_1 doi: 10.1016/j.toxlet.2009.03.004 – volume: 52 start-page: 794 year: 2004 ident: e_1_2_7_57_1 article-title: Free radicals and antioxidants in human health: current status and future prospects publication-title: J Assoc Physicians India contributor: fullname: Devasagayam TPT |
| SSID | ssj0009656 |
| Score | 2.4486158 |
| Snippet | Silver nanoparticles (AgNPs) are antibacterial materials widely used in numerous products and medical supplies. Previously, we showed that AgNPs trigger... Abstract Silver nanoparticles (AgNPs) are antibacterial materials widely used in numerous products and medical supplies. Previously, we showed that AgNPs... |
| SourceID | proquest crossref pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1039 |
| SubjectTerms | Acetylcysteine Antibacterial materials Apoptosis Biological fertilization Blastocysts Body weight Cascades Caspase Cyclin-dependent kinase inhibitor p21 Embryogenesis Embryonic development Embryonic growth stage Fetuses Impairment In vitro fertilization In vivo methods and tests Intravenous administration Maturation Nanoparticles Oocytes p53 Protein Pretreatment Reactive oxygen species Regulatory mechanisms (biology) Silver |
| Title | Hazardous impacts of silver nanoparticles on mouse oocyte maturation and fertilization and fetal development through induction of apoptotic processes |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/29964317 https://www.proquest.com/docview/2101929905/abstract/ |
| Volume | 33 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ti9QwEA7riSCC6Pm2ekoQvx1du-lrPsp5UgQV5A7PTyXpJtyCtIvbgt7_8Pf415zppOlWTzj9UpbsJqWdZ5OZ5JlnGHuxsljoyGZBnFoVoPpdoMLcBqE2aqlSqTSxLd6nxWn89iw5m81-7rCWulYvqotL80r-x6rQBnbFLNl_sKwfFBrgM9gXrmBhuF7JxoW6AAMjiZWSHXtaxnaNZOfDWtUQDzvaGx4JYIxvDpum-t4iaRX1NtqBi2yRXf3FpWS6FsySXI2UIl_RB4J4UpztKQSbZtM2KPq6oYwDR0kc9vrHNDoktTff1tVkG7_o3Hb10TlMMZ54UWw7j9nP5pyyR9b-63fDcku0hH7e_DTpvu7cL9x-xjL3zDg_BUNAG4dUyGVhhjaIAwQV-xnmbRLQGPAZ7szCeLy9s6JDxCkvXS1IfRYefgGzGlUtnSpy_7ZSev4iaT2LErqWfddr7LrIZILR_-uPo36ZTPvywf6RBmmrULz0d506RH-Jcnpv5-QOu-3CFP6K8HOXzUy9z24ck_X22a0PlQF8kdr5PfbDA5E7IPLGcgIinwCRNzXvgcgJiHwEIgfY8QkQXQtAh-8AkTsgcg9EvJkHIvdAvM9O3xyfHBWBq_cRVFEStkFsDLgBWgpkBxhh4OVEmRYmXCmlZWoFau3ZFBX_bJZVeZSqXINHLKtY2krb6AHbq5vaPGLcAgKSROW5NnmcyyqPNUQWkVYCj_qlnbPnw0svNyTrUv5h1Dk7GMxRun_9thRLDIrAh0vm7CGZyI8AzSk65I-vMvoTdnOE_wHba7925ik4uK1-1oPoF-F9rdU |
| link.rule.ids | 315,786,790,27957,27958 |
| linkProvider | Wiley-Blackwell |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hazardous+impacts+of+silver+nanoparticles+on+mouse+oocyte+maturation+and+fertilization+and+fetal+development+through+induction+of+apoptotic+processes&rft.jtitle=Environmental+toxicology&rft.au=Huang%2C+Chien%E2%80%90Hsun&rft.au=Yeh%2C+Jui%E2%80%90Ming&rft.au=Chan%2C+Wen%E2%80%90Hsiung&rft.date=2018-10-01&rft.issn=1520-4081&rft.eissn=1522-7278&rft.volume=33&rft.issue=10&rft.spage=1039&rft.epage=1049&rft_id=info:doi/10.1002%2Ftox.22590&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_tox_22590 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1520-4081&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1520-4081&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1520-4081&client=summon |