Actual driving performance and psychomotor function in healthy subjects after acute and subchronic treatment with escitalopram, mirtazapine, and placebo: a crossover trial

• Published in: The journal of clinical psychiatry Vol. 66; no. 4; p. 436
• Main Authors: Wingen, Marleen, Bothmer, John, Langer, Stefan, Ramaekers, Johannes G
• Format: Journal Article
• Language: English
• Published: United States 01.04.2005
• Subjects: Adult; Affect - drug effects; Antidepressive Agents, Tricyclic - adverse effects; Antidepressive Agents, Tricyclic - pharmacology; Automobile Driving - psychology; Circadian Rhythm; Citalopram - adverse effects; Citalopram - pharmacology; Computer Simulation; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fatigue - chemically induced; Female; Humans; Male; Mianserin - adverse effects; Mianserin - analogs & derivatives; Mianserin - pharmacology; Mirtazapine; Neuropsychological Tests - statistics & numerical data; Placebos; Psychomotor Performance - drug effects; Serotonin Uptake Inhibitors - adverse effects; Serotonin Uptake Inhibitors - pharmacology; Sleep Initiation and Maintenance Disorders - chemically induced

The effects of escitalopram 10 to 20 mg/day and mirtazapine 30 to 45 mg/day on actual driving and psychomotor performance of 18 healthy subjects were determined in a randomized, double-blind, placebo-controlled, multiple-dose, 3-way crossover trial. Each treatment period lasted for 15 days and was s...