Serotonin and the mammalian circadian system: I. In vitro phase shifts by serotonergic agonists and antagonists

• Published in: Journal of biological rhythms Vol. 8; no. 1; p. 1
• Main Authors: Prosser, R A, Dean, R R, Edgar, D M, Heller, H C, Miller, J D
• Format: Journal Article
• Language: English
• Published: United States 01.04.1993
• Subjects: 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology; Animals; Autoradiography; Circadian Rhythm - drug effects; Dose-Response Relationship, Drug; Electrophysiology; In Vitro Techniques; Iodocyanopindolol; Lysergic Acid Diethylamide - pharmacology; Male; Metergoline - pharmacology; Neurons - drug effects; Neurons - physiology; Pindolol - analogs & derivatives; Pindolol - pharmacology; Quipazine - pharmacology; Rats; Rats, Wistar; Receptors, Serotonin - drug effects; Serotonin - physiology; Serotonin Antagonists - pharmacology; Serotonin Receptor Agonists - pharmacology; Suprachiasmatic Nucleus - drug effects; Suprachiasmatic Nucleus - physiology
• ISSN: 0748-7304
• DOI: 10.1177/074873049300800101

The primary mammalian circadian clock, located in the suprachiasmatic nuclei (SCN), receives a major input from the raphe nuclei. The role of this input is largely unknown, and is the focus of this research. The SCN clock survives in vitro, where it produces a 24-hr rhythm in spontaneous neuronal ac...