High Myopia Is Not Associated with the SNPs in the TGIF, Lumican, TGFB1, and HGF Genes

• Published in: Investigative ophthalmology & visual science Vol. 50; no. 4; pp. 1546 - 1551
• Main Authors: Wang, Panfeng, Li, Shiqiang, Xiao, Xueshan, Jia, Xiaoyun, Jiao, Xiaodong, Guo, Xiangming, Zhang, Qingjiong
• Format: Journal Article
• Language: English
• Published: Rockville, MD ARVO 01.04.2009; Association for Research in Vision and Ophtalmology
• Subjects: Adult; Alleles; Asian Continental Ancestry Group - genetics; Biological and medical sciences; China - epidemiology; Chondroitin Sulfate Proteoglycans - genetics; DNA Primers - chemistry; Extracellular Matrix Proteins - genetics; Eye and associated structures. Visual pathways and centers. Vision; Fundamental and applied biological sciences. Psychology; Gene Frequency; Genotype; Hepatocyte Growth Factor - genetics; Homeodomain Proteins - genetics; Humans; Keratan Sulfate - genetics; Lumican; Medical sciences; Myopia, Degenerative - genetics; Ophthalmology; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide - genetics; Repressor Proteins - genetics; Transforming Growth Factor beta - genetics; Vertebrates: nervous system and sense organs; Vision disorders; Eye disease; Association; Gene; Vision disorder; Refractive error; High myopia; Ophthalmology

Four single-nucleotide polymorphisms (SNPs) in the TGIF, lumican, TGFB1, and HGF genes have been declared to be associated with high myopia in Chinese living in southeast China, but none of them has been confirmed by additional studies. This study was conducted to verify the reported positive associ...