A comprehensive strategy for the development of a multi-epitope vaccine targeting Treponema pallidum, utilizing heat shock proteins, encompassing the entire process from vaccine design to in vitro evaluation of immunogenicity

• Published in: Frontiers in microbiology Vol. 16; p. 1551437
• Main Authors: Jiang, Jing, Xu, Linglan, Wang, Xuefeng, Wang, Ming, Cao, Youde, Li, Ranhui, Zheng, Kang, Wu, Xian
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 19.03.2025
• Subjects: heat shock protein; immune stimulation; immunoinformatic; Microbiology; reverse vaccinology; subtractive proteomics; Treponema pallidum; vaccine; subtractive proteomics; reverse vaccinology; heat shock protein; immune stimulation; immunoinformatic; Treponema pallidum

, the causative spirochete of syphilis, is primarily transmitted through sexual contact and has emerged as a significant global health concern. To address this issue, enhancing diagnostic capabilities, strengthening public health interventions, and developing a safe and effective vaccine are critica...