The stimulation of arginine transport by TNFα in human endothelial cells depends on NF-κB activation

• Published in: Biochimica et biophysica acta. Biomembranes Vol. 1664; no. 1; pp. 45 - 52
• Main Authors: Visigalli, Rossana, Bussolati, Ovidio, Sala, Roberto, Barilli, Amelia, Rotoli, Bianca Maria, Parolari, Alessandro, Alamanni, Francesco, Gazzola, Gian C, Dall'Asta, Valeria
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2004
• Subjects: CAT transporter; NFκB; SLC7 gene; TNFα; IFNγ; TNFα; NFκB; PDTC; M199; CFPD; MG132; PPM-18; CAPE; IL-1β; SB203580; LPS; SP600125; SLC7 gene; NOS; DRB; FBS; NEM; PD98059; HSVECs; CAT transporter; EBSS; HUVECs

In human saphenous vein endothelial cells (HSVECs), tumor necrosis factor-α (TNFα) and bacterial lipopolysaccharide (LPS), but neither interferon γ (IFNγ) nor interleukin 1β (IL-1β), stimulate arginine transport. The effects of TNFα and LPS are due solely to the enhancement of system y + activity, w...