Color-encoded microcarriers based on nano-silicon dioxide film for multiplexed immunoassays
Multiplexed analysis allows researchers to obtain high-density information with minimal assay time, sample volume and cost. Currently, microcarrier or particle-based approaches for multiplexed analysis involve complicated or expensive encoding and decoding processes. In this paper, a novel optical e...
Saved in:
| Published in | Analyst (London) Vol. 137; no. 16; pp. 3760 - 3766 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge
Royal Society of Chemistry
21.08.2012
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Multiplexed analysis allows researchers to obtain high-density information with minimal assay time, sample volume and cost. Currently, microcarrier or particle-based approaches for multiplexed analysis involve complicated or expensive encoding and decoding processes. In this paper, a novel optical encoding technique based on nano-silicon dioxide film is presented. Microcarriers composed of thermally grown silicon dioxide (SiO(2)) film and monocrystalline silicon (Si) substrate were fabricated. The nano-silicon dioxide film exhibited unique surface color by low-coherence interference. Hence the colors can be used for encoding at least 100 microcarriers loaded with films of different thickness. We demonstrated that color-encoded microcarriers loaded with antigens could be used for multiplexed immunoassays to detect goat anti-human IgG, goat anti-mouse IgG and goat anti-rabbit IgG, with fluorescent detection as the interrogating approach. This microcarrier-based method also exhibited improved analytical performance compared with a microarray technique. This approach will provide new opportunities for multiplexed target assay development. |
|---|---|
| AbstractList | Multiplexed analysis allows researchers to obtain high-density information with minimal assay time, sample volume and cost. Currently, microcarrier or particle-based approaches for multiplexed analysis involve complicated or expensive encoding and decoding processes. In this paper, a novel optical encoding technique based on nano-silicon dioxide film is presented. Microcarriers composed of thermally grown silicon dioxide (SiO(2)) film and monocrystalline silicon (Si) substrate were fabricated. The nano-silicon dioxide film exhibited unique surface color by low-coherence interference. Hence the colors can be used for encoding at least 100 microcarriers loaded with films of different thickness. We demonstrated that color-encoded microcarriers loaded with antigens could be used for multiplexed immunoassays to detect goat anti-human IgG, goat anti-mouse IgG and goat anti-rabbit IgG, with fluorescent detection as the interrogating approach. This microcarrier-based method also exhibited improved analytical performance compared with a microarray technique. This approach will provide new opportunities for multiplexed target assay development.Multiplexed analysis allows researchers to obtain high-density information with minimal assay time, sample volume and cost. Currently, microcarrier or particle-based approaches for multiplexed analysis involve complicated or expensive encoding and decoding processes. In this paper, a novel optical encoding technique based on nano-silicon dioxide film is presented. Microcarriers composed of thermally grown silicon dioxide (SiO(2)) film and monocrystalline silicon (Si) substrate were fabricated. The nano-silicon dioxide film exhibited unique surface color by low-coherence interference. Hence the colors can be used for encoding at least 100 microcarriers loaded with films of different thickness. We demonstrated that color-encoded microcarriers loaded with antigens could be used for multiplexed immunoassays to detect goat anti-human IgG, goat anti-mouse IgG and goat anti-rabbit IgG, with fluorescent detection as the interrogating approach. This microcarrier-based method also exhibited improved analytical performance compared with a microarray technique. This approach will provide new opportunities for multiplexed target assay development. Multiplexed analysis allows researchers to obtain high-density information with minimal assay time, sample volume and cost. Currently, microcarrier or particle-based approaches for multiplexed analysis involve complicated or expensive encoding and decoding processes. In this paper, a novel optical encoding technique based on nano-silicon dioxide film is presented. Microcarriers composed of thermally grown silicon dioxide (SiO sub(2)) film and monocrystalline silicon (Si) substrate were fabricated. The nano-silicon dioxide film exhibited unique surface color by low-coherence interference. Hence the colors can be used for encoding at least 100 microcarriers loaded with films of different thickness. We demonstrated that color-encoded microcarriers loaded with antigens could be used for multiplexed immunoassays to detect goat anti-human IgG, goat anti-mouse IgG and goat anti-rabbit IgG, with fluorescent detection as the interrogating approach. This microcarrier-based method also exhibited improved analytical performance compared with a microarray technique. This approach will provide new opportunities for multiplexed target assay development. Multiplexed analysis allows researchers to obtain high-density information with minimal assay time, sample volume and cost. Currently, microcarrier or particle-based approaches for multiplexed analysis involve complicated or expensive encoding and decoding processes. In this paper, a novel optical encoding technique based on nano-silicon dioxide film is presented. Microcarriers composed of thermally grown silicon dioxide (SiO(2)) film and monocrystalline silicon (Si) substrate were fabricated. The nano-silicon dioxide film exhibited unique surface color by low-coherence interference. Hence the colors can be used for encoding at least 100 microcarriers loaded with films of different thickness. We demonstrated that color-encoded microcarriers loaded with antigens could be used for multiplexed immunoassays to detect goat anti-human IgG, goat anti-mouse IgG and goat anti-rabbit IgG, with fluorescent detection as the interrogating approach. This microcarrier-based method also exhibited improved analytical performance compared with a microarray technique. This approach will provide new opportunities for multiplexed target assay development. |
| Author | Li, Qiang Zhang, Kaihuan Lin, Haixiao Lu, Ying Wang, Tongzhou Huang, Guoliang Zhou, Xinying Wang, Jia Wang, Chen Li, Xin |
| Author_xml | – sequence: 1 givenname: Qiang surname: Li fullname: Li, Qiang – sequence: 2 givenname: Kaihuan surname: Zhang fullname: Zhang, Kaihuan – sequence: 3 givenname: Tongzhou surname: Wang fullname: Wang, Tongzhou – sequence: 4 givenname: Xinying surname: Zhou fullname: Zhou, Xinying – sequence: 5 givenname: Jia surname: Wang fullname: Wang, Jia – sequence: 6 givenname: Chen surname: Wang fullname: Wang, Chen – sequence: 7 givenname: Haixiao surname: Lin fullname: Lin, Haixiao – sequence: 8 givenname: Xin surname: Li fullname: Li, Xin – sequence: 9 givenname: Ying surname: Lu fullname: Lu, Ying – sequence: 10 givenname: Guoliang surname: Huang fullname: Huang, Guoliang |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26192822$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22745929$$D View this record in MEDLINE/PubMed |
| BookMark | eNqN0UtLxDAQB_Agiq6Pix9AehFEqObRtMlRFl-w4EVPHso0TSCSJmvSwu63N4urgnjwFCb8Zpj8c4h2ffAaoVOCrwhm8lpR8IxXBMMOmhFWVyXnVOyiGcaYlbTm1QE6TOktlwRzvI8OKG0qLqmcodd5cCGW2qvQ674YrIpBQYxWx1R0kPJd8IUHH8pknVW56G1Y2V4XxrqhMCEWw-RGu3R6lbEdhskHSAnW6RjtGXBJn2zPI_Ryd_s8fygXT_eP85tFqRjHY8k4E5zqrm86mZ-jKKYgZW0EFo02QhFeUdJ1uu6p6FQtjNAKm6pvGIGmriQ7Qhefc5cxvE86je1gk9LOgddhSm0OSdAqj-H_oLTJWuANPdvSqRt03y6jHSCu26_sMjjfAkgKnInglU0_riaSCkqzu_x0OdqUojbfhODNbrL9-cCM8S-s7AijDX6MYN1fLR8QIZz9 |
| CODEN | ANALAO |
| CitedBy_id | crossref_primary_10_1016_j_aca_2016_08_031 crossref_primary_10_1021_acsabm_0c00200 crossref_primary_10_1021_nn5072792 crossref_primary_10_1039_C9AN00343F crossref_primary_10_1039_C5LC00488H crossref_primary_10_1364_OL_38_001524 |
| Cites_doi | 10.1038/416885a 10.1126/science.294.5540.137 10.1364/JOSAB.28.000721 10.1021/nl062453t 10.1126/science.1134929 10.1038/nmat702 10.1016/j.cccn.2005.06.023 10.1007/s00216-005-0225-0 10.1002/cyto.990210302 10.1039/b911525k 10.1093/clinchem/43.9.1749 10.1038/90228 10.1039/b703457a 10.1126/science.1896858 10.1016/S0167-7799(01)01844-3 10.1038/nrd817 10.1117/1.2358957 10.1002/1097-0320(20010101)43:1<23::AID-CYTO1015>3.0.CO;2-D 10.1038/35015701 10.1021/ac034165c 10.1089/154065803762851379 10.1016/j.cocis.2011.01.005 10.1073/pnas.97.14.7692 10.1021/ac071082d 10.1364/OE.16.007102 10.1038/364555a0 |
| ContentType | Journal Article |
| Copyright | 2015 INIST-CNRS |
| Copyright_xml | – notice: 2015 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 7SR 7U5 8BQ 8FD JG9 L7M |
| DOI | 10.1039/c2an35410a |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Engineered Materials Abstracts Solid State and Superconductivity Abstracts METADEX Technology Research Database Materials Research Database Advanced Technologies Database with Aerospace |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Materials Research Database Engineered Materials Abstracts Solid State and Superconductivity Abstracts Technology Research Database Advanced Technologies Database with Aerospace METADEX |
| DatabaseTitleList | MEDLINE - Academic Materials Research Database MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1364-5528 |
| EndPage | 3766 |
| ExternalDocumentID | 22745929 26192822 10_1039_c2an35410a |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -~X .GJ .HR 0-7 0R~ 0UZ 186 1TJ 23M 2WC 3EH 3O- 4.4 53G 5RE 705 70~ 71~ 7~J AAEMU AAIWI AAJAE AAMEH AANOJ AAWGC AAXHV AAXPP AAYXX ABASK ABDVN ABEMK ABJNI ABOCM ABPDG ABRYZ ABXOH ACGFS ACHDF ACIWK ACLDK ACRPL ADMRA ADNMO ADSRN ADXHL AEFDR AENEX AENGV AESAV AETIL AFFNX AFLYV AFOGI AFRZK AFVBQ AGEGJ AGKEF AGQPQ AGRSR AHGCF AHGXI AIDUJ AKMSF ALMA_UNASSIGNED_HOLDINGS ALSGL ANBJS ANLMG ANUXI APEMP AQHUZ ASKNT ASPBG AUDPV AVWKF AZFZN BBWZM BLAPV BSQNT C1A C6K CAG CITATION COF CS3 EBS ECGLT EE0 EEHRC EF- EJD F5P GGIMP GNO H13 HZ~ H~N IDY IDZ J3G J3H J3I L-8 LPU M4U MVM N9A NDZJH O9- P2P R56 R7B R7E RAOCF RCLXC RCNCU RIG RNS ROL RPMJG RRA RRC RRXOS RSCEA SC5 SKM SKR SKZ SLC SLF SLH TN5 UPT VH6 WH7 XOL XXG ZCG ZKB ZXP ~02 IQODW CGR CUY CVF ECM EIF NPM 7X8 7SR 7U5 8BQ 8FD JG9 L7M |
| ID | FETCH-LOGICAL-c350t-353852ebd7b9039c202a996f8087ef8c15421bbe6d28bc68f8ec0f4d731a76493 |
| ISSN | 0003-2654 1364-5528 |
| IngestDate | Fri Jul 11 13:02:33 EDT 2025 Fri Jul 11 07:42:40 EDT 2025 Thu Apr 03 07:07:01 EDT 2025 Mon Jul 21 09:16:14 EDT 2025 Tue Jul 01 02:26:21 EDT 2025 Thu Apr 24 23:12:17 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 16 |
| Keywords | Performance evaluation Chemical analysis High density Microanalysis IgG Rabbit Time Immunological method Target Silicon Human Sample Use Rodentia Color Interference Lagomorpha Chemical sensor Antigen Thickness Substrate Vertebrata Mammalia Mouse Volume Technique Detection Sensor array |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c350t-353852ebd7b9039c202a996f8087ef8c15421bbe6d28bc68f8ec0f4d731a76493 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 22745929 |
| PQID | 1027038805 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_1038241545 proquest_miscellaneous_1027038805 pubmed_primary_22745929 pascalfrancis_primary_26192822 crossref_primary_10_1039_c2an35410a crossref_citationtrail_10_1039_c2an35410a |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2012-08-21 |
| PublicationDateYYYYMMDD | 2012-08-21 |
| PublicationDate_xml | – month: 08 year: 2012 text: 2012-08-21 day: 21 |
| PublicationDecade | 2010 |
| PublicationPlace | Cambridge |
| PublicationPlace_xml | – name: Cambridge – name: England |
| PublicationTitle | Analyst (London) |
| PublicationTitleAlternate | Analyst |
| PublicationYear | 2012 |
| Publisher | Royal Society of Chemistry |
| Publisher_xml | – name: Royal Society of Chemistry |
| References | Evans (c2an35410a-(cit23)/*[position()=1]) 2003; 1 Janda (c2an35410a-(cit12)/*[position()=1]) 2000; 97 Pregibon (c2an35410a-(cit3)/*[position()=1]) 2007; 315 Chan (c2an35410a-(cit17)/*[position()=1]) 2007; 7 Doyle (c2an35410a-(cit14)/*[position()=1]) 2011; 16 Cunin (c2an35410a-(cit11)/*[position()=1]) 2002; 1 Zhi (c2an35410a-(cit13)/*[position()=1]) 2003; 75 Braeckmans (c2an35410a-(cit1)/*[position()=1]) 2002; 1 Nolan (c2an35410a-(cit18)/*[position()=1]) 1995; 21 Graves (c2an35410a-(cit19)/*[position()=1]) 2001; 43 Dunbar (c2an35410a-(cit9)/*[position()=1]) 2006; 363 Fodor (c2an35410a-(cit5)/*[position()=1]) 1993; 364 Pauly (c2an35410a-(cit2)/*[position()=1]) 2009; 134 Nicewarner-Pena (c2an35410a-(cit22)/*[position()=1]) 2001; 294 Doyle (c2an35410a-(cit21)/*[position()=1]) 2007; 7 Gershon (c2an35410a-(cit4)/*[position()=1]) 2002; 416 Nolan (c2an35410a-(cit16)/*[position()=1]) 2002; 20 Wang (c2an35410a-(cit24)/*[position()=1]) 2011; 28 Penn (c2an35410a-(cit20)/*[position()=1]) 2006; 384 Zhao (c2an35410a-(cit25)/*[position()=1]) 2008; 16 Lockhart (c2an35410a-(cit7)/*[position()=1]) 2000; 405 Gao (c2an35410a-(cit26)/*[position()=1]) 2007; 79 Cao (c2an35410a-(cit15)/*[position()=1]) 2006; 11 Barinaga (c2an35410a-(cit8)/*[position()=1]) 1991; 253 Nie (c2an35410a-(cit10)/*[position()=1]) 2001; 19 Fulton (c2an35410a-(cit6)/*[position()=1]) 1997; 43 |
| References_xml | – volume: 416 start-page: 885 year: 2002 ident: c2an35410a-(cit4)/*[position()=1] publication-title: Nature doi: 10.1038/416885a – volume: 294 start-page: 137 year: 2001 ident: c2an35410a-(cit22)/*[position()=1] publication-title: Science doi: 10.1126/science.294.5540.137 – volume: 28 start-page: 721 year: 2011 ident: c2an35410a-(cit24)/*[position()=1] publication-title: J. Opt. Soc. Am. B doi: 10.1364/JOSAB.28.000721 – volume: 7 start-page: 351 year: 2007 ident: c2an35410a-(cit17)/*[position()=1] publication-title: Nano Lett. doi: 10.1021/nl062453t – volume: 315 start-page: 1393 year: 2007 ident: c2an35410a-(cit3)/*[position()=1] publication-title: Science doi: 10.1126/science.1134929 – volume: 1 start-page: 39 year: 2002 ident: c2an35410a-(cit11)/*[position()=1] publication-title: Nat. Mater. doi: 10.1038/nmat702 – volume: 363 start-page: 71 year: 2006 ident: c2an35410a-(cit9)/*[position()=1] publication-title: Clin. Chim. Acta doi: 10.1016/j.cccn.2005.06.023 – volume: 384 start-page: 658 year: 2006 ident: c2an35410a-(cit20)/*[position()=1] publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-005-0225-0 – volume: 21 start-page: 223 year: 1995 ident: c2an35410a-(cit18)/*[position()=1] publication-title: Cytometry doi: 10.1002/cyto.990210302 – volume: 134 start-page: 2028 year: 2009 ident: c2an35410a-(cit2)/*[position()=1] publication-title: Analyst doi: 10.1039/b911525k – volume: 43 start-page: 1749 year: 1997 ident: c2an35410a-(cit6)/*[position()=1] publication-title: Clin. Chem. doi: 10.1093/clinchem/43.9.1749 – volume: 19 start-page: 631 year: 2001 ident: c2an35410a-(cit10)/*[position()=1] publication-title: Nat. Biotechnol. doi: 10.1038/90228 – volume: 7 start-page: 818 year: 2007 ident: c2an35410a-(cit21)/*[position()=1] publication-title: Lab Chip doi: 10.1039/b703457a – volume: 253 start-page: 1489 year: 1991 ident: c2an35410a-(cit8)/*[position()=1] publication-title: Science doi: 10.1126/science.1896858 – volume: 20 start-page: 9 year: 2002 ident: c2an35410a-(cit16)/*[position()=1] publication-title: Trends Biotechnol. doi: 10.1016/S0167-7799(01)01844-3 – volume: 1 start-page: 447 year: 2002 ident: c2an35410a-(cit1)/*[position()=1] publication-title: Nat. Rev. Drug Discovery doi: 10.1038/nrd817 – volume: 11 start-page: 054025 year: 2006 ident: c2an35410a-(cit15)/*[position()=1] publication-title: J. Biomed. Opt. doi: 10.1117/1.2358957 – volume: 43 start-page: 23 year: 2001 ident: c2an35410a-(cit19)/*[position()=1] publication-title: Cytometry doi: 10.1002/1097-0320(20010101)43:1<23::AID-CYTO1015>3.0.CO;2-D – volume: 405 start-page: 827 year: 2000 ident: c2an35410a-(cit7)/*[position()=1] publication-title: Nature doi: 10.1038/35015701 – volume: 75 start-page: 4125 year: 2003 ident: c2an35410a-(cit13)/*[position()=1] publication-title: Anal. Chem. doi: 10.1021/ac034165c – volume: 1 start-page: 199 year: 2003 ident: c2an35410a-(cit23)/*[position()=1] publication-title: Assay Drug Dev. Technol. doi: 10.1089/154065803762851379 – volume: 16 start-page: 106 year: 2011 ident: c2an35410a-(cit14)/*[position()=1] publication-title: Curr. Opin. Colloid Interface Sci. doi: 10.1016/j.cocis.2011.01.005 – volume: 97 start-page: 7692 year: 2000 ident: c2an35410a-(cit12)/*[position()=1] publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.97.14.7692 – volume: 79 start-page: 7589 year: 2007 ident: c2an35410a-(cit26)/*[position()=1] publication-title: Anal. Chem. doi: 10.1021/ac071082d – volume: 16 start-page: 7102 year: 2008 ident: c2an35410a-(cit25)/*[position()=1] publication-title: Opt. Express doi: 10.1364/OE.16.007102 – volume: 364 start-page: 555 year: 1993 ident: c2an35410a-(cit5)/*[position()=1] publication-title: Nature doi: 10.1038/364555a0 |
| SSID | ssj0001050 |
| Score | 2.0579822 |
| Snippet | Multiplexed analysis allows researchers to obtain high-density information with minimal assay time, sample volume and cost. Currently, microcarrier or... |
| SourceID | proquest pubmed pascalfrancis crossref |
| SourceType | Aggregation Database Index Database Enrichment Source |
| StartPage | 3760 |
| SubjectTerms | Analytical chemistry Animals Chemistry Color Dioxides Encoding Exact sciences and technology General, instrumentation Goats Humans Immunoassay - economics Immunoassay - methods Microtechnology - methods Miscellaneous Models, Theoretical Multiplexing Nanocomposites Nanomaterials Nanostructure Nanostructures - chemistry Optical Phenomena Silicon Dioxide - chemistry Silicon substrates |
| Title | Color-encoded microcarriers based on nano-silicon dioxide film for multiplexed immunoassays |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22745929 https://www.proquest.com/docview/1027038805 https://www.proquest.com/docview/1038241545 |
| Volume | 137 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZtcmihhL67fQSV9lKCG1uSbfkYwoa0XVIKXrrQg5ElOTEkcljbkOTXZ-TH2ku3Je3FLGKQ15pP0ow08w1CHyXPWJql1GHCE-CgRKkjNPUcS9XOZCSUJ5poi5PgeM6-LvzFUN6qyS6p0s_yZmNeyf9oFdpArzZL9h80u-oUGuA36BeeoGF43knH4PUXS8dSUSqwGy9sbJ0US1uDrtyz25OyVwFGmMIp83NQudlTeXGVK23pmC6aCMM-oPAKhHObK1KANS2uy7HR2hKXVOPqH6vjg1kTDfADQHb62xn0N5Gf1QP6fnbNcWFOb86KepAvatu-yM11v5F25xA2oIM7bXJzt3TSgDm-36V66w1t_Xrbsrz0wBovnzZCZ-O67lJLiyqJMNRnnjvavfob-5PvydF8Nkvi6SK-j7YJeA2w7G0fTOMvs9XWDMZkmzbe_a2er5ZG-0PfaxbKo0tRwmTJ2ionf3ZDGnMkfox2Oj8CH7SgeILuafMUPTjsy_c9Q7_WwIHXwIEbcODC4DE4cAcObMGBARx4BA48BsdzND-axofHTldJw5HUdyuHwrbmE52qMI3gYyVxiQBHN-MuD3XGJdjRxEtTHSjCUxnwjGvpZkyF1BNhwCL6Am2ZwuhXCGc0kIGCaWy52TyRCS8ICFHcVywDy8adoE_96CWyo5m31U7OkybcgUbJMNIT9GEle9mSq2yU2l1Twkq0cf7BwJ2g971WEhhke-MljC7qEnoiYUN35P9NhnJrxjKQedmqdHgDCZkPDsTrO7zhDXo4TIu3aKta1vodGKxVutvB8BYyTZne |
| linkProvider | Royal Society of Chemistry |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Color-encoded+microcarriers+based+on+nano-silicon+dioxide+film+for+multiplexed+immunoassays&rft.jtitle=Analyst+%28London%29&rft.au=Li%2C+Qiang&rft.au=Zhang%2C+Kaihuan&rft.au=Wang%2C+Tongzhou&rft.au=Zhou%2C+Xinying&rft.date=2012-08-21&rft.issn=1364-5528&rft.eissn=1364-5528&rft.volume=137&rft.issue=16&rft.spage=3760&rft_id=info:doi/10.1039%2Fc2an35410a&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-2654&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-2654&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-2654&client=summon |