Estrogen augments glucose transporter and IGF1 expression in primate cerebral cortex

• Published in: The FASEB journal Vol. 15; no. 6; p. 907
• Main Authors: Cheng, C M, Cohen, M, Wang, J, Bondy, C A
• Format: Journal Article
• Language: English
• Published: United States 01.04.2001
• Subjects: Animals; Antineoplastic Agents, Hormonal - pharmacology; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Estradiol - pharmacology; Female; Gene Expression - drug effects; Glucose Transporter Type 3; Glucose Transporter Type 4; Insulin-Like Growth Factor I - biosynthesis; Macaca mulatta; Monosaccharide Transport Proteins - biosynthesis; Monosaccharide Transport Proteins - genetics; Muscle Proteins; Nerve Tissue Proteins; Receptor, IGF Type 1 - biosynthesis; RNA, Messenger - biosynthesis; RNA, Messenger - drug effects; Tamoxifen - pharmacology

Estrogen has many positive effects on neural tissue in experimental model systems, including stimulation of neurite growth and neurotransmitter synthesis and protection against diverse types of neural injury. In humans, estrogen treatment is reputed to protect against Alzheimer's disease. To in...